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Keywords:

  • drug delivery;
  • ultrasound;
  • insulin delivery;
  • diabetes;
  • nano-network
Thumbnail image of graphical abstract

The integration of an injectable insulin-encapsulated nano-network with a focused ultrasound system (FUS) can remotely regulate insulin release both in vitro and in vivo. A single subcutaneous injection of the nano-network with intermittent FUS administration facilitates reduction of the blood glucose levels in type 1 diabetic mice for up to 10 d.