Stem Cells: Phenotypic and Transcriptional Modulation of Human Pluripotent Stem Cells Induced by Nano/Microfabrication Materials (Adv. Healthcare Mater. 2/2013)

Authors

  • Ken-ichiro Kamei,

    Corresponding author
    1. Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto, 606-8501, Japan
    Current affiliation:
    1. These authors contributed equally to this work.
    • Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto, 606-8501, Japan
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  • Yoshikazu Hirai,

    1. Department of Micro Engineering, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto, 606-8501, Japan
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Momoko Yoshioka,

    1. Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto, 606-8501, Japan
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  • Yoshihide Makino,

    1. Department of Micro Engineering, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto, 606-8501, Japan
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  • Qinghua Yuan,

    1. Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto, 606-8501, Japan
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  • Minako Nakajima,

    1. Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto, 606-8501, Japan
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  • Yong Chen,

    1. Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto, 606-8501, Japan
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  • Osamu Tabata

    Corresponding author
    1. Department of Micro Engineering, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto, 606-8501, Japan
    • Department of Micro Engineering, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto, 606-8501, Japan.
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Abstract

original image

Polymer-based microfabrication materials such as polydimethylsiloxane (PDMS) and photoresists (PRs) permit the creation of nano/microstructured substrates that enable the direct control of the cellular functions and phenotypes of human pluripotent stem cells (hPSCs), but their biocompatibility and effects on hPSCs are poorly understood. On page 287, Osamu Tabata, Kenichiro Kamei, and co-workers reveal that the tested materials preferentially direct hPSCs towards differentiation. The image depicts how PRs (yellow), PDMS (light blue) and glass (white) influence the capability of hPSC differentiation into various tissues, such as muscle, heart and neurons.

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