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Keywords:

  • DNA;
  • drug delivery;
  • nanomedicine;
  • nanoparticles;
  • pH-responsive
Thumbnail image of graphical abstract

A novel pH-responsive DNA–gold nanoparticle conjugate that has high drug load, resists non-specific serum protein adsorption and has high endocytotic cellular uptake is developed by Dejian Zhou, Rongjun Chen, and co-workers on page 275. Upon acidification in intracellular endosomes/lysosomes, the formation of intramolecular i-motif by the pH-responsive DNA leads to efficient, pH-triggered release of the anticancer drugs inside cancer cells, and hence high cytotoxicity.