Imaging: Conjugated Polymer Amplified Far-Red/Near-Infrared Fluorescence from Nanoparticles with Aggregation-Induced Emission Characteristics for Targeted In Vivo Imaging (Adv. Healthcare Mater. 3/2013)

Authors

  • Dan Ding,

    1. Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore
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  • Kai Li,

    1. Institute of Materials Research Engineering, 3 Research Link, 117602, Singapore
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  • Wei Qin,

    1. Department of Chemistry, Institute for Advanced Study, State Key Laboratory of Molecular Neuroscience, Institute of Molecular Functional Materials, and Division of Biomedical Engineering, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China
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  • Ruoyu Zhan,

    1. Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore
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  • Yong Hu,

    1. National Laboratory of Solid-State Microstructure, Department of Material Science and Engineering, Nanjing University, Nanjing 210093, China
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  • Jianzhao Liu,

    1. Department of Chemistry, Institute for Advanced Study, State Key Laboratory of Molecular Neuroscience, Institute of Molecular Functional Materials, and Division of Biomedical Engineering, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China
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  • Ben Zhong Tang,

    1. Department of Chemistry, Institute for Advanced Study, State Key Laboratory of Molecular Neuroscience, Institute of Molecular Functional Materials, and Division of Biomedical Engineering, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China
    2. Institute of Materials Research Engineering, 3 Research Link, 117602, Singapore
    3. South China University of Technology (SCUT)-HKUST, Joint Research Laboratory, Guangdong Innovative Research Team, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China
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  • Bin Liu

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore
    2. Institute of Materials Research Engineering, 3 Research Link, 117602, Singapore
    • Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore.
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Abstract

original image

Bin Liu and co-workers report on page 500 a fluorescence-amplified far-red/near-infrared (FR/NIR) probe by co-encapsulation of a conjugated polymer donor and a fluorogen acceptor with aggregation-induced emission (AIE) characteristics into biocompatible bovine serum albumin (BSA) matrix. These probes allow for targeted in vitro and in vivo cancer imaging with high contrast and in a selective manner.

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