Cancer Therapy: Optically Traceable Solid Lipid Nanoparticles Loaded with siRNA and Paclitaxel for Synergistic Chemotherapy with In situ Imaging (Adv. Healthcare Mater. 4/2013)

Authors

  • Ki Hyun Bae,

    1. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseung-gu, Daejeon, 305-701, Republic of Korea
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Jeong Yu Lee,

    1. Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseung-gu, Daejeon, 305-701, Republic of Korea
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Soo Hyeon Lee,

    1. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseung-gu, Daejeon, 305-701, Republic of Korea
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  • Tae Gwan Park,

    1. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseung-gu, Daejeon, 305-701, Republic of Korea
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  • Yoon Sung Nam

    Corresponding author
    1. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseung-gu, Daejeon, 305-701, Republic of Korea
    2. Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseung-gu, Daejeon, 305-701, Republic of Korea
    3. KAIST Institute of NanoCentury (KINC) and BioCentury (KIB), Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseung-gu, Daejeon, 305-701, Republic of Korea
    • Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseung-gu, Daejeon, 305-701, Republic of Korea.
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Abstract

original image

Optically traceable, low-density lipoprotein (LDL)-mimetic solid lipid nanoparticles (SLNs) loaded with Bcl-2 siRNA, paclitaxel, and CdSe/ZnS quantum dots for synergistic combination chemotherapy are reported by Yoon Sung Nam and co-workers on page 576. The LDL-mimetic SLNs deliver both paclitaxel and siRNA and exhibit synergistic anticancer activities through caspase-mediated apoptosis. The strong fluorescence from the quantum dots enables in situ optical monitoring of drug delivery.

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