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Keywords:

  • theranostics;
  • cancer therapy;
  • solid lipid nanoparticles;
  • quantum dots;
  • paclitaxel;
  • siRNA
Thumbnail image of graphical abstract

Optically traceable, low-density lipoprotein (LDL)-mimetic solid lipid nanoparticles (SLNs) loaded with Bcl-2 siRNA, paclitaxel, and CdSe/ZnS quantum dots for synergistic combination chemotherapy are reported by Yoon Sung Nam and co-workers on page 576. The LDL-mimetic SLNs deliver both paclitaxel and siRNA and exhibit synergistic anticancer activities through caspase-mediated apoptosis. The strong fluorescence from the quantum dots enables in situ optical monitoring of drug delivery.