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Keywords:

  • platinum (IV) pro-drug;
  • NaYF4;
  • drug delivery;
  • folic acid;
  • up-conversion cell imaging
Thumbnail image of graphical abstract

A folic acid targeted anticancer drug delivery system based on Pt (IV) complexes pro-drug conjugated upconversion NaYF4:Yb3+/Er3+ nanoparticles is developed. As reported by Jun Lin, Ping'an Ma, and co-workers on page 562, the platinum (IV) complexes as pro-drugs can exhibit anti-cancer activities when the platinum (IV) complexes are reduced to platinum (II) in the intracellular environment. The nanoparticles show bright upconversion fluorescence under 980 nm laser excitation; thus, the as-prepared nanoparticles can be used as a luminescent probe for up-conversion cell imaging.