Drug Delivery: Antibody-Functionalized Porous Silicon Nanoparticles for Vectorization of Hydrophobic Drugs (Adv. Healthcare Mater. 5/2013)



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Biodegradable porous silicon nanoparticles (pSiNP) functionalized with cancer cell targeting antibodies and loaded with the hydrophobic anti-cancer drug camptothecin are developed by Nicolas H. Voelcker, Frédérique Cunin, and co-workers on page 718. High targeting and killing efficiency is demonstrated in vitro on three types of cancer cells: neuroblastoma, glioblastoma and lymphoma cells.