Biomaterials: Nanowell-Trapped Charged Ligand-Bearing Nanoparticle Surfaces: A Novel Method of Enhancing Flow-Resistant Cell Adhesion (Adv. Healthcare Mater. 7/2013)

Authors

  • Phat L. Tran,

    1. Biomedical Engineering Graduate Interdisciplinary, Program and Department of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721, USA
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  • Jessica R. Gamboa,

    1. Biomedical Engineering Graduate Interdisciplinary, Program and Department of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721, USA
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  • Katherine E. McCracken,

    1. Department of Agricultural and Biosystems Engineering, The University of Arizona, Tucson, Arizona 85721, USA
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  • Mark R. Riley,

    1. Department of Agricultural and Biosystems Engineering, The University of Arizona, Tucson, Arizona 85721, USA
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  • Marvin J. Slepian,

    Corresponding author
    1. Biomedical Engineering Graduate Interdisciplinary, Program and Department of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721, USA
    2. Sarver Heart Center and Department of Medicine, College of Medicine, The University of Arizona, Tucson, Arizona 85721, USA
    • Biomedical Engineering Graduate Interdisciplinary, Program and Department of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721, USA.
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  • Jeong-Yeol Yoon

    Corresponding author
    1. Biomedical Engineering Graduate Interdisciplinary, Program and Department of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721, USA
    2. Department of Agricultural and Biosystems Engineering, The University of Arizona, Tucson, Arizona 85721, USA
    • Biomedical Engineering Graduate Interdisciplinary, Program and Department of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721, USA.
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Abstract

original image

Jeong-Yeol Yoon, Marvin J. Slepian, and co-workers describe on page 1019 a novel method utilizing nanofabrication techniques to create surfaces with enhanced endothelial adhesion and retention under flow. The system utilizes nano texture, charge, and ligands all combined together, uniquely assembled on the substrata surface, to create ensemble nanotextured surfaces. This new method may be of particular utility for enhancing flow-resistant endothelialization of cardiovascular devices.

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