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Keywords:

  • actin;
  • gliding motility;
  • hydrogels;
  • jasplakinolide;
  • Apicomplexa
Thumbnail image of graphical abstract

Sporozoite motility is essential for malaria transmission and constitutes the first target for intervention within the human body. On page 1162 J. P. Spatz, F. Frischknecht, and co-workers use a set of tunable substrates with changed ligand spacing and elasticity to show that a small chemical compound that stabilizes the actin cytoskeleton can compensate the motility defects of parasites that lack a surface protein important for substrate adhesion.