Drug Delivery: Targeted and pH-Responsive Delivery of Doxorubicin to Cancer Cells Using Multifunctional Dendrimer-Modified Multi-Walled Carbon Nanotubes (Adv. Healthcare Mater. 9/2013)

Authors

  • Shihui Wen,

    1. State Key Laboratory for Modification of Chemical, Fibers and Polymer Materials, Donghua University, Shanghai 201620, People's Republic of China
    2. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China
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  • Hui Liu,

    1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China
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  • Hongdong Cai,

    1. State Key Laboratory for Modification of Chemical, Fibers and Polymer Materials, Donghua University, Shanghai 201620, People's Republic of China
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  • Mingwu Shen,

    1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China
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  • Xiangyang Shi

    Corresponding author
    1. State Key Laboratory for Modification of Chemical, Fibers and Polymer Materials, Donghua University, Shanghai 201620, People's Republic of China
    2. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China
    3. CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal
    • State Key Laboratory for Modification of Chemical, Fibers and Polymer Materials, Donghua University, Shanghai 201620, People's Republic of China.
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Abstract

original image

Xiangyang Shi and co-workers show on page 1267 that the unique combination of dendrimer chemistry and carbon nanotubes allows the generation of multifunctional nanodevices for high-payload encapsulation of a model anticancer drug doxorubicin with pH-responsive release behavior and targeting specificity, providing an efficient strategy for targeted cancer therapy.

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