Imaging: High Relaxivities and Strong Vascular Signal Enhancement for NaGdF4 Nanoparticles Designed for Dual MR/Optical Imaging (Adv. Healthcare Mater. 11/2013)

Authors

  • Rafik Naccache,

    1. Department of Chemistry and Biochemistry and Centre for NanoScience Research, Concordia University, Montréal, Québec, H4B 1R6, Canada
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  • Pascale Chevallier,

    1. Centre de recherche du Centre hospitalier universitaire de, Québec (CR-CHUQ), Québec, G1L 3L5, Canada
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  • Jean Lagueux,

    1. Centre de recherche du Centre hospitalier universitaire de, Québec (CR-CHUQ), Québec, G1L 3L5, Canada
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  • Yves Gossuin,

    1. Service de physique expérimentale et biologique, Université de Mons, Mons, B7000, Belgium
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  • Sophie Laurent,

    1. Service de chimie générale, organique et biomédicale, Université de Mons, Mons, B7000, Belgium
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  • Luce Vander Elst,

    1. Service de chimie générale, organique et biomédicale, Université de Mons, Mons, B7000, Belgium
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  • Cornelia Chilian,

    1. Ecole Polytechnique de Montréal, Montréal, Québec, H3T 1J4, Canada
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  • John A. Capobianco,

    Corresponding author
    1. Department of Chemistry and Biochemistry and Centre for NanoScience Research, Concordia University, Montréal, Québec, H4B 1R6, Canada
    • John A. Capobianco, Department of Chemistry and Biochemistry and Centre for NanoScience Research, Concordia University, Montréal, Québec, H4B 1R6, Canada

      Marc-André Fortin, Centre de recherche du Centre hospitalier universitaire de Québec, (CR-CHUQ), Québec, G1L 3L5, Canada, Département de génie des mines, de la métallurgie et des matériaux and Centre de recherche sur, les matériaux avancés (CERMA), Université Laval, Québec, G1V 0A6, Canada.

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  • Marc-André Fortin

    Corresponding author
    1. Centre de recherche du Centre hospitalier universitaire de Québec, (CR-CHUQ), Québec, G1L 3L5, Canada, Département de génie des mines, de la métallurgie et des matériaux and Centre de recherche sur, les matériaux avancés (CERMA), Université Laval, Québec, G1V 0A6, Canada
    • John A. Capobianco, Department of Chemistry and Biochemistry and Centre for NanoScience Research, Concordia University, Montréal, Québec, H4B 1R6, Canada

      Marc-André Fortin, Centre de recherche du Centre hospitalier universitaire de Québec, (CR-CHUQ), Québec, G1L 3L5, Canada, Département de génie des mines, de la métallurgie et des matériaux and Centre de recherche sur, les matériaux avancés (CERMA), Université Laval, Québec, G1V 0A6, Canada.

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Abstract

original image

Tripositive gadolinium-ion doped NIR-to-NIR upconverting paramagnetic nanoparticles are efficiently detected are NIR imaging techniques but can also provide efficient “positive” contrast in MRI. On page 1478 John A. Capobianco, Marc-André Fortin, and co-workers show that citrate-coated nanoparticles present the lowest relaxometric ratios reported for NaGdF4 nanoparticle suspensions. IV-injected nanoparticles evidence long blood retention times in mice while biodistribution studies show elimination through the reticuloendothelial and urinary systems.

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