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Keywords:

  • assembly;
  • cortex;
  • hippocampus;
  • neural network;
  • three-dimensional neural tissue
Thumbnail image of graphical abstract

A millimeter-sized neural component, named neural building block (NBB), is formed by using massive amount of neuronal spheroids from a single specific brain region. By assembling different NBBs, Shoji Takeuchi and co-workers show, on page 1564, how 3D heterogeneous macroscopic neural tissue can be fabricated without any scaffold materials. This method offers high cell density cultures, and neurons in this system show complex millimeter-scale axonal extensions into 3D spatial areas.