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Keywords:

  • differentiation;
  • embryonic stem cells;
  • gold nanoparticles;
  • nanotopography;
  • self-renewal
Thumbnail image of graphical abstract

On page 1644, Molly M. Stevens and team show how embryonic stem cells can sense nanoscale topography and chemistry from surfaces composed of 4.5 nm gold monolayer-protected metal nanoparticles with varying shell composition. Early differentiation markers are influenced by both variables, suggesting a synergistic role for topographical features and surface chemistry in influencing stem cell behavior.