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Multifunctional Skin-Like Electronics for Quantitative, Clinical Monitoring of Cutaneous Wound Healing

Authors

  • Yoshiaki Hattori,

    1. Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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  • Leo Falgout,

    1. Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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  • Woosik Lee,

    1. Department of Electrical Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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  • Sung-Young Jung,

    1. Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea
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  • Emily Poon,

    1. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • Jung Woo Lee,

    1. Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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  • Ilyoun Na,

    1. I. Na, Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea
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  • Amelia Geisler,

    1. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • Divya Sadhwani,

    1. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • Yihui Zhang,

    1. Department of Civil and Environmental Engineering, Department of Mechanical Engineering, Center for Engineering and Health and Skin Disease Research Center, Northwestern University, Evanston, IL, USA
    2. Center for Mechanics and Materials, Beijing, China
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  • Yewang Su,

    1. Department of Civil and Environmental Engineering, Department of Mechanical Engineering, Center for Engineering and Health and Skin Disease Research Center, Northwestern University, Evanston, IL, USA
    2. Center for Mechanics and Materials, Beijing, China
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  • Xiaoqi Wang,

    1. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • Zhuangjian Liu,

    1. Institute of High Performance Computing, Connexis, Singapore
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  • Jing Xia,

    1. Department of Civil and Environmental Engineering, Department of Mechanical Engineering, Center for Engineering and Health and Skin Disease Research Center, Northwestern University, Evanston, IL, USA
    2. Center for Mechanics and Materials, Beijing, China
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  • Huanyu Cheng,

    1. Department of Civil and Environmental Engineering, Department of Mechanical Engineering, Center for Engineering and Health and Skin Disease Research Center, Northwestern University, Evanston, IL, USA
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  • R. Chad Webb,

    1. Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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  • Andrew P. Bonifas,

    1. Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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  • Philip Won,

    1. Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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  • Jae-Woong Jeong,

    1. Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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  • Kyung-In Jang,

    1. Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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  • Young Min Song,

    1. Department of Electronic Engineering, Busan, Republic of Korea
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  • Beatrice Nardone,

    1. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • Michael Nodzenski,

    1. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • Jonathan A. Fan,

    1. Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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  • Yonggang Huang,

    1. Department of Civil and Environmental Engineering, Department of Mechanical Engineering, Center for Engineering and Health and Skin Disease Research Center, Northwestern University, Evanston, IL, USA
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  • Dennis P. West,

    1. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • Amy S. Paller,

    1. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • Murad Alam,

    1. Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
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  • Woon-Hong Yeo,

    Corresponding author
    1. Department of Mechanical and Nuclear Engineering and Institute for Engineering and Medicine, Virginia Commonwealth University, Richmond, VA, USA
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  • John A. Rogers

    Corresponding author
    1. Department of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA
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Abstract

Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of “epidermal” electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management.

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