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A Platform for Controlled Dual-Drug Delivery to the Retina: Protective Effects against Light-Induced Retinal Damage in Rats

Authors

  • Nobuhiro Nagai,

    1. Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan
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  • Hirokazu Kaji,

    1. Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, Aoba-ku, Sendai, Japan
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  • Hideyuki Onami,

    1. Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan
    2. Department of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan
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  • Yuki Katsukura,

    1. Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan
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  • Yumi Ishikawa,

    1. Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan
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  • Zhaleh Kashkouli Nezhad,

    1. Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan
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  • Kaori Sampei,

    1. Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan
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  • Satoru Iwata,

    1. Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan
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  • Shuntaro Ito,

    1. Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, Aoba-ku, Sendai, Japan
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  • Matsuhiko Nishizawa,

    1. Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, Aoba-ku, Sendai, Japan
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  • Toru Nakazawa,

    1. Department of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan
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  • Noriko Osumi,

    1. Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan
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  • Yukihiko Mashima,

    1. R-tech Ueno Ltd., Chiyoda-ku, Tokyo, Japan
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  • Toshiaki Abe

    Corresponding author
    1. Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan
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Abstract

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Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which are made of photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal neuroprotection against light injury in rats when compared with single-drug-loaded devices. The device would offer a safer therapeutic method than intravitreal injections for retinal disease treatments.

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