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Keywords:

  • ROS-responsiveness;
  • cyclodextrin;
  • nanomedicine;
  • drug delivery;
  • tumor targeting
Thumbnail image of graphical abstract

A novel reactive oxygen species (ROS)-responsive nanoplatform can be successfully manufactured from a ROS-triggerable β-cyclodextrin material. Extensive in vitro and in vivo studies validate that this nanoscaled system may serve as a new drug delivery vehicle with well-defined ROS-sensitivity and superior biocompatibility. This nanocarrier can be used for ROS-triggered transport of diverse therapeutics and imaging agents.