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Keywords:

  • microneedles;
  • vaccines;
  • hydrogels;
  • cutaneous delivery
Thumbnail image of graphical abstract

Composite silk/PAA microneedles structure stabilizes sensitive biological molecules at room temperature, and then allows rapid disintegration in the skin following application through dissolution of the PAA polymer. On page 47, Darrell J. Irvine, Paula T. Hammond, and co-workers, show how silk hydrogel tips are then implanted in the skin tissue to sustain delivery, while PAA-loaded agents are released in a single local bolus.