Micropatterning: Site-Specific Differentiation of Neural Stem Cell Regulated by Micropatterned Multicomponent Interfaces (Adv. Healthcare Mater. 2/2014)

Authors

  • Ying Wang,

    1. 83 Tat Chee Ave, AC1-P6423, Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, China
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  • Zhen Xu,

    1. 83 Tat Chee Ave, AC1-P6423, Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, China
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  • Lance C. Kam,

    1. Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, New York 10027, USA
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  • Peng Shi

    Corresponding author
    1. 83 Tat Chee Ave, AC1-P6423, Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, China
    • 83 Tat Chee Ave, AC1-P6423, Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, China.

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Abstract

original image

A multicomponent interface with patterns of multiple bio-active proteins is created and used by Peng Shi and team to study the cooperative involvement of cell-matrix interaction and cell–cell signaling in regulating stem cell functions. On page 214, local presentation of notch signaling ligand or cell adhesion molecule effectively modulate the balance between cell–cell and cell–matrix interaction in neural stem cells (NSCs), and significantly change the differentiation toward neuronal or glial lineages.

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