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Keywords:

  • micropatterning;
  • stem cell differentiation;
  • cell–cell communication;
  • cell–matrix interaction;
  • multicomponent interfaces
Thumbnail image of graphical abstract

A multicomponent interface with patterns of multiple bio-active proteins is created and used by Peng Shi and team to study the cooperative involvement of cell-matrix interaction and cell–cell signaling in regulating stem cell functions. On page 214, local presentation of notch signaling ligand or cell adhesion molecule effectively modulate the balance between cell–cell and cell–matrix interaction in neural stem cells (NSCs), and significantly change the differentiation toward neuronal or glial lineages.