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Keywords:

  • artificial vasculature;
  • gelatin hydrogel;
  • microfibers;
  • poly(N-isopropylacrylamide);
  • tissue engineering
Thumbnail image of graphical abstract

A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N-isopropylacrylamide) microfibers. The capillary-like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.