A Hydrophobic Dye-Encapsulated Nano-Hybrid as an Efficient Fluorescent Probe for Living Cell Imaging (pages 475–479)
Shu Chang, Xumeng Wu, Yongsheng Li, Dechao Niu, Zhi Ma, Wenru Zhao, Jinlou Gu, Wenjie Dong, Feng Ding, Weihong Zhu and Jianlin Shi
Article first published online: 5 JUN 2012 | DOI: 10.1002/adhm.201200144
Water-soluble hydrophobic-dye@nano-hybrids (DPN@NHs) with extraordinarily enhanced fluorescent performance were fabricated by encapsulating the hydrophobic dye molecules into the core of the hybrid nanospheres based on the self-assembly of amphiphilic block copolymers followed by shell cross-linking using 3-mercaptopropyltrimethoxy-silane. The DPN@NHs are 50 nm in size, are monodispersed in aqueous solution and have a quantum yield enhanced by 30 times.