Novel Biopolymers to Enhance Endothelialisation of Intra-vascular Devices (pages 646–656)
Salvatore Pernagallo, Olga Tura, Mei Wu, Kay Samuel, Juan J. Diaz-Mochon, Anna Hansen, Rong Zhang, Melany Jackson, Gareth J. Padfield, Patrick W.F. Hadoke, Nicholas L. Mills, Marc L. Turner, John P. Iredale, David C. Hay and Mark Bradley
Article first published online: 9 AUG 2012 | DOI: 10.1002/adhm.201200130
Rapid endothelisation is of critical importance in the prevention of adverse remodelling after device implantation. Currently, there is a need for alternative strategies to promote re-endothelialisation for intravascular stents and vascular grafts. Using polymer microarray technology 345 polymers are comprehensively assessed and a matrix is identified that specifically supports both progenitor and mature endothelial cell activity in vitro and in vivo while minimising platelet attachment.