In Vivo Treatment of Propionibacterium acnes Infection with Liposomal Lauric Acids (pages 1322–1328)
Dissaya Pornpattananangkul, Victoria Fu, Soracha Thamphiwatana, Li Zhang, Michael Chen, James Vecchio, Weiwei Gao, Chun-Ming Huang and Liangfang Zhang
Article first published online: 12 MAR 2013 | DOI: 10.1002/adhm.201300002
This article reports the development and in vivo evaluation of liposomal lauric acids (LipoLA) as a new, effective, and safe nanotherapeutic agent for the treatment of Propionibacterium acnes infection. Using a mouse ear model, topically applying LipoLA in a gel form onto the infectious site results in completely killing the bacteria without inducing acute toxicity to normal skin.