Advanced Healthcare Materials

Cover image for Vol. 2 Issue 11

November, 2013

Volume 2, Issue 11

Pages 1413–1531

  1. Cover Picture

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      Micropatterning: Micropatterning Hydrophobic Liquid on a Porous Polymer Surface for Long-Term Selective Cell-Repellency (Adv. Healthcare Mater. 11/2013) (page 1413)

      Erica Ueda and Pavel A. Levkin

      Version of Record online: 7 NOV 2013 | DOI: 10.1002/adhm.201370053

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      Erica Ueda and Pavel A. Levkin present a simple method to produce precise micropatterns of hydrophobic liquids by using hydrophilic–hydrophobic substrates. On page 1425, these micropatterns are shown to possess long-term stability, excellent cell-repellency, no cytotoxicity, and higher efficiency than conventional PEG or superhydrophobic surfaces in controlling eukaryotic cell adhesion.

  2. Inside Front Cover

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    4. Masthead
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      Drug Solubility: Mesoporous Calcium Carbonate as a Phase Stabilizer of Amorphous Celecoxib – An Approach to Increase the Bioavailability of Poorly Soluble Pharmaceutical Substances (Adv. Healthcare Mater. 11/2013) (page 1414)

      Johan Forsgren, Mattias Andersson, Peter Nilsson and Albert Mihranyan

      Version of Record online: 7 NOV 2013 | DOI: 10.1002/adhm.201370054

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      On page 1469, Johan Forsgren, Albert Mihranyan, and co-workers show how vaterite is used as a phase stabilizer of amorphous celecoxib, resulting in the increase of the apparent aqueous solubility of the substance. The presented results show promise for the use of vaterite to achieve enhanced bioavailability in new formulations of Type II BCS drugs.

  3. Masthead

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      Masthead: (Adv. Healthcare Mater. 11/2013)

      Version of Record online: 7 NOV 2013 | DOI: 10.1002/adhm.201370055

  4. Contents

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Communications
    7. Full Papers
    8. Frontispiece
    9. Full Papers
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  5. Communications

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    1. Antibody-Functionalized Magnetic Polymersomes: In vivo Targeting and Imaging of Bone Metastases using High Resolution MRI (pages 1420–1424)

      Line Pourtau, Hugo Oliveira, Julie Thevenot, Yali Wan, Alain R. Brisson, Olivier Sandre, Sylvain Miraux, Eric Thiaudiere and Sébastien Lecommandoux

      Version of Record online: 19 APR 2013 | DOI: 10.1002/adhm.201300061

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      Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody-labeled polymersomes at the tumor site.

    2. Micropatterning Hydrophobic Liquid on a Porous Polymer Surface for Long-Term Selective Cell-Repellency (pages 1425–1429)

      Erica Ueda and Pavel A. Levkin

      Version of Record online: 28 MAY 2013 | DOI: 10.1002/adhm.201300073

      Thumbnail image of graphical abstract

      A simple method to form precise micropatterns of hydrophobic liquids using porous hydrophilic–hydrophobic substrates is presented. The micropatterns of hydrophobic liquid exhibit long-term stability, excellent cell-repellency, no cytotoxicity, and are more efficient than conventional PEG or superhydrophobic surfaces in controlling eukaryotic cell adhesion.

    3. Manipulating Magnetic 3D Spheroids in Hanging Drops for Applications in Tissue Engineering and Drug Screening (pages 1430–1434)

      Vincent H. B. Ho, Wei Mei Guo, Charlotte L. Huang, Shu Fen Ho, Su Yin Chaw, Ern Yu Tan, Kee Woei Ng and Joachim S.C. Loo

      Version of Record online: 19 APR 2013 | DOI: 10.1002/adhm.201200408

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      Magnetic spheroid manipulation can be carried out in hanging drops to generate distinctly structured heterotypic microtissues through sequential addition of cells or spheroid to homotypic spheroids. These spheroids can also be incorporated in a droplet-based assay to screen for therapeutic efficacy in prolonged studies. This simple and versatile technique can offer potential benefits in tissue engineering and drug screening applications.

    4. pH-Controlled Delivery of Nanoparticles into Tumor Cells (pages 1435–1439)

      Liang Han, Haojun Ma, Yubo Guo, Yuyang Kuang, Xi He and Chen Jiang

      Version of Record online: 8 APR 2013 | DOI: 10.1002/adhm.201300013

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      Nanoparticles target tumor cells by pH-controlled means. Nanoparticles carry three synergistic delivery functions: 1) tumor tissue targeting by the EPR effect; 2) tumor cell targeting by pHLIP-mediated membrane-localization; and 3) tumor cell uptake by adsorptive-mediated endocytosis.

    5. Delivery of Proteases in Aqueous Two-Phase Systems Enables Direct Purification of Stem Cell Colonies from Feeder Cell Co-Cultures for Differentiation into Functional Cardiomyocytes (pages 1440–1444)

      John P. Frampton, Huilin Shi, Albert Kao, Jack M. Parent and Shuichi Takayama

      Version of Record online: 17 APR 2013 | DOI: 10.1002/adhm.201300049

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      Patterning of bioactive enzymes with subcellular resolution is achieved by dispensing droplets of dextran (DEX) onto polyethylene glycol (PEG)-covered cells though a glass capillary needle connected to a pneumatic pump. This technique is applied to purify colonies of induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblast (MEF) feeder cultures and inefficiently induced iPSC colonies by selectively dissociating the iPSCs with proteases.

    6. Combined Effect of Mussel-Inspired Surface Modification and Topographical Cues on the Behavior of Skeletal Myoblasts (pages 1445–1450)

      Sook Hee Ku and Chan Beum Park

      Version of Record online: 15 APR 2013 | DOI: 10.1002/adhm.201300067

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      The combined effect of mussel-inspired polydopamine (PDA) surface functionalization and topographical cues on the behavior of skeletal myoblasts is described. On PDA-modified nanofibers, myogenic protein expression and the fusion of myoblasts are increased significantly compared with those on unmodified nanofibers. The multinucleate myotubes on the aligned nanofibers are oriented in a direction parallel to the nanofibers.

  6. Full Papers

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    1. Oil-Filled Lipid Nanoparticles Containing 2′-(2-Bromohexadecanoyl)-Docetaxel for the Treatment of Breast Cancer (pages 1451–1457)

      Lan Feng, Soumya R. Benhabbour and Russell J. Mumper

      Version of Record online: 19 APR 2013 | DOI: 10.1002/adhm.201300017

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      Oil-filled lipid nanoparticles (NPs) have excellent compatibility with medium-chain ester derivatives of docetaxel (DX). The synthesized DX lipid conjugate enhances the drug loading, entrapment and retention in liquid oil-filled lipid NPs. The stable anchoring of DX lipid conjugate in the long-circulating NPs leads to significant enhancements in blood exposure and efficacy in vivo.

    2. The Copolymer of Poly(2-dimethylaminoethyl methacrylate) and Methacrylated Chondroitin Sulfate with Low Cytotoxicity for Gene Delivery (pages 1458–1468)

      Yu-Lun Lo, Yao-Sheng Wang and Li-Fang Wang

      Version of Record online: 25 APR 2013 | DOI: 10.1002/adhm.201200373

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      An anionic crosslinker is synthesized based on a natural polysaccharide, chondroitin sulfate (CS), by introducing methacrylate groups (CSMA). By systematic adjustment of the substitution degree of methacrylation on CS and the weight percent of CSMA and poly(2-dimethylaminoethyl methacrylate) (PDMAEMA), sol-type copolymers are obtained as a gene-delivery vector. The combination of CS and PDMAEMA not only reduces the cytotoxicity of PDMAEMA, but also facilitates better transfection efficiency than PDMAEMA because of the recognition of CS by CD44 receptors on cell surfaces.

    3. Mesoporous Calcium Carbonate as a Phase Stabilizer of Amorphous Celecoxib – An Approach to Increase the Bioavailability of Poorly Soluble Pharmaceutical Substances (pages 1469–1476)

      Johan Forsgren, Mattias Andersson, Peter Nilsson and Albert Mihranyan

      Version of Record online: 23 MAY 2013 | DOI: 10.1002/adhm.201200391

      Thumbnail image of graphical abstract

      Vaterite (CaCO3) is used as a phase stabilizer of amorphous celecoxib to increase the apparent aqueous solubility of the substance. The effect is attributed to the mesoporous structure of the particles that constrain the ability for the celecoxib to crystallize. The results demonstrate the feasibility of using vaterite, which is already recognized as GRAS by the FDA, as an excipient for increasing the oral bioavailability for Type II BCS drugs.

  7. Frontispiece

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Communications
    7. Full Papers
    8. Frontispiece
    9. Full Papers
    1. You have free access to this content
      Imaging: High Relaxivities and Strong Vascular Signal Enhancement for NaGdF4 Nanoparticles Designed for Dual MR/Optical Imaging (Adv. Healthcare Mater. 11/2013) (page 1477)

      Rafik Naccache, Pascale Chevallier, Jean Lagueux, Yves Gossuin, Sophie Laurent, Luce Vander Elst, Cornelia Chilian, John A. Capobianco and Marc-André Fortin

      Version of Record online: 7 NOV 2013 | DOI: 10.1002/adhm.201370057

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      Tripositive gadolinium-ion doped NIR-to-NIR upconverting paramagnetic nanoparticles are efficiently detected are NIR imaging techniques but can also provide efficient “positive” contrast in MRI. On page 1478 John A. Capobianco, Marc-André Fortin, and co-workers show that citrate-coated nanoparticles present the lowest relaxometric ratios reported for NaGdF4 nanoparticle suspensions. IV-injected nanoparticles evidence long blood retention times in mice while biodistribution studies show elimination through the reticuloendothelial and urinary systems.

  8. Full Papers

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Communications
    7. Full Papers
    8. Frontispiece
    9. Full Papers
    1. High Relaxivities and Strong Vascular Signal Enhancement for NaGdF4 Nanoparticles Designed for Dual MR/Optical Imaging (pages 1478–1488)

      Rafik Naccache, Pascale Chevallier, Jean Lagueux, Yves Gossuin, Sophie Laurent, Luce Vander Elst, Cornelia Chilian, John A. Capobianco and Marc-André Fortin

      Version of Record online: 13 MAY 2013 | DOI: 10.1002/adhm.201300060

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      Lanthanide-doped sodium gadolinium fluoride upconverting nanoparticles are shown to efficiently decrease the relaxation time of protons in aqueous media and provide a positive contrast in MRI applications. In particular, ultrasmall nanoparticles that are less than 5 nm in diameter are shown to have the lowest relaxometric ratios reported to date and a very strong vascular enhancement for times of at least 90 min in the mouse model.

    2. Confocal Raman Imaging Study Showing Macrophage Mediated Biodegradation of Graphene In Vivo (pages 1489–1500)

      Chundayil Madathil Girish, Abhilash Sasidharan, G. Siddaramana Gowd, Shantikumar Nair and Manzoor Koyakutty

      Version of Record online: 2 APR 2013 | DOI: 10.1002/adhm.201200489

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      Biodegradability of graphene is a crucial issue concerning the clinical translation of graphene based nano-bio systems. This confocal Raman imaging study reveals clear evidence of macrophage mediated degradation of tissue bound graphene under in vivo conditions over a period of 90 days in mouse models. In vitro studies conducted in macrophage cell lines also support the in vivo observations.

    3. Upconversion Nanoparticles Conjugated with Gd3+-DOTA and RGD for Targeted Dual-Modality Imaging of Brain Tumor Xenografts (pages 1501–1512)

      Jiefu Jin, Zhenhua Xu, Yue Zhang, Yan-Juan Gu, Michael Hon-Wah Lam and Wing-Tak Wong

      Version of Record online: 30 APR 2013 | DOI: 10.1002/adhm.201300102

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      A peptide-labeled paramagnetic/upconversion nanoprobe (UCNP-Gd-RGD) is designed and synthesized. It demonstrates high specificity towards U87MG cells and preferential retention in subcutaneous U87MG tumors. The tumor boundary delineation is successfully achieved through in vivo upconversion fluorescence and MRI studies. This dual-modal nanoprobe holds the potentials in preoperative MR imaging and intra-operative fluorescence-guided surgery

    4. Arsonium-Containing Lipophosphoramides, Poly-Functional Nano-Carriers for Simultaneous Antibacterial Action and Eukaryotic Cell Transfection (pages 1513–1524)

      Tony Le Gall, Mathieu Berchel, Sophie Le Hir, Aurore Fraix, Jean Yves Salaün, Claude Férec, Pierre Lehn, Paul-Alain Jaffrès and Tristan Montier

      Version of Record online: 26 APR 2013 | DOI: 10.1002/adhm.201200478

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      In contrast to compounds exhibiting no (Z+ = N+) or insufficient (Z+ = P+) antibacterial effectiveness, arsonium (Z+ = As+)-containing lipophosphoramides can simultaneously inhibit bacteria while safely and efficiently delivering DNA into eukaryotic cells, thereby leading to luciferase (Luc) reporter gene expression. Such poly-functional nano-carriers may therefore be particularly suitable for gene therapy strategies under infected conditions such as within the airways of cystic fibrosis patients.

    5. Bacterial Cellulose Nanofibrillar Patch as a Wound Healing Platform of Tympanic Membrane Perforation (pages 1525–1531)

      Jangho Kim, Seung Won Kim, Subeom Park, Ki Taek Lim, Hoon Seonwoo, Yeonju Kim, Byung Hee Hong, Yun-Hoon Choung and Jong Hoon Chung

      Version of Record online: 4 APR 2013 | DOI: 10.1002/adhm.201200368

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      A bacterial cellulose (BC) nanofibrillar patch is proposed as a new wound healing platform for tympanic membrane (TM) perforation. In vitro and in vivo studies demonstrate that the BC nanofibrillar patch promotes the TM healing speed and rate as well as recover the function of TM.

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