High Relaxivities and Strong Vascular Signal Enhancement for NaGdF4 Nanoparticles Designed for Dual MR/Optical Imaging (pages 1478–1488)
Rafik Naccache, Pascale Chevallier, Jean Lagueux, Yves Gossuin, Sophie Laurent, Luce Vander Elst, Cornelia Chilian, John A. Capobianco and Marc-André Fortin
Version of Record online: 13 MAY 2013 | DOI: 10.1002/adhm.201300060
Lanthanide-doped sodium gadolinium fluoride upconverting nanoparticles are shown to efficiently decrease the relaxation time of protons in aqueous media and provide a positive contrast in MRI applications. In particular, ultrasmall nanoparticles that are less than 5 nm in diameter are shown to have the lowest relaxometric ratios reported to date and a very strong vascular enhancement for times of at least 90 min in the mouse model.