Advanced Healthcare Materials

Cover image for Vol. 2 Issue 4

April, 2013

Volume 2, Issue 4

Pages 513–619

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Progress Report
    8. Frontispiece
    9. Communications
    10. Full Papers
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      Cancer Therapy: Optically Traceable Solid Lipid Nanoparticles Loaded with siRNA and Paclitaxel for Synergistic Chemotherapy with In situ Imaging (Adv. Healthcare Mater. 4/2013) (page 513)

      Ki Hyun Bae, Jeong Yu Lee, Soo Hyeon Lee, Tae Gwan Park and Yoon Sung Nam

      Version of Record online: 5 APR 2013 | DOI: 10.1002/adhm.201370018

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      Optically traceable, low-density lipoprotein (LDL)-mimetic solid lipid nanoparticles (SLNs) loaded with Bcl-2 siRNA, paclitaxel, and CdSe/ZnS quantum dots for synergistic combination chemotherapy are reported by Yoon Sung Nam and co-workers on page 576. The LDL-mimetic SLNs deliver both paclitaxel and siRNA and exhibit synergistic anticancer activities through caspase-mediated apoptosis. The strong fluorescence from the quantum dots enables in situ optical monitoring of drug delivery.

  2. Inside Front Cover

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Progress Report
    8. Frontispiece
    9. Communications
    10. Full Papers
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      Drug Delivery: Platinum (IV) Pro-Drug Conjugated NaYF4:Yb3+/Er3+ Nanoparticles for Targeted Drug Delivery and Up-Conversion Cell Imaging (Adv. Healthcare Mater. 4/2013) (page 514)

      Yunlu Dai, Xiaojiao Kang, Dongmei Yang, Xuejiao Li, Xiao Zhang, Chunxia Li, Zhiyao Hou, Ziyong Cheng, Ping'an Ma and Jun Lin

      Version of Record online: 5 APR 2013 | DOI: 10.1002/adhm.201370019

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      A folic acid targeted anticancer drug delivery system based on Pt (IV) complexes pro-drug conjugated upconversion NaYF4:Yb3+/Er3+ nanoparticles is developed. As reported by Jun Lin, Ping'an Ma, and co-workers on page 562, the platinum (IV) complexes as pro-drugs can exhibit anti-cancer activities when the platinum (IV) complexes are reduced to platinum (II) in the intracellular environment. The nanoparticles show bright upconversion fluorescence under 980 nm laser excitation; thus, the as-prepared nanoparticles can be used as a luminescent probe for up-conversion cell imaging.

  3. Back Cover

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Progress Report
    8. Frontispiece
    9. Communications
    10. Full Papers
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      Stem Cells: Surface Bound Amine Functional Group Density Influences Embryonic Stem Cell Maintenance (Adv. Healthcare Mater. 4/2013) (page 624)

      Frances Harding, Renee Goreham, Robert Short, Krasimir Vasilev and Nicolas H. Voelcker

      Version of Record online: 5 APR 2013 | DOI: 10.1002/adhm.201370020

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      The back cover image shows an octadiene–allylamine plasma polymer gradient surface with colonies of embryonic stem cells attached, as described by Nicolas H. Voelcker and co-workers on page 585. Stem cell colonies spread out on regions of the surface with higher amine group density, differentiating into more mature cell types. In contrast, smaller rounded colonies, consisting of proliferating stem cells, form high methyl group density areas.

  4. Masthead

    1. Top of page
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    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Progress Report
    8. Frontispiece
    9. Communications
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      Masthead: (Adv. Healthcare Mater. 4/2013)

      Version of Record online: 5 APR 2013 | DOI: 10.1002/adhm.201370021

  5. Contents

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Progress Report
    8. Frontispiece
    9. Communications
    10. Full Papers
    1. You have free access to this content
  6. Progress Report

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Progress Report
    8. Frontispiece
    9. Communications
    10. Full Papers
    1. Bioresponsive Hydrogels (pages 520–532)

      A. Nolan Wilson and Anthony Guiseppi-Elie

      Version of Record online: 10 DEC 2012 | DOI: 10.1002/adhm.201200332

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      Bioresponsive hydrogels have tremendous potential for applications, from bioactive controlled release to bioactuation. This review discusses the progress in the engineering approaches to address the challenge of bioresponsive hydrogels by design and suggests design rules with some very specific and illustrative examples. The use of feedback and feedforward control to achieve regulation of metabolic activity are discussed.

  7. Frontispiece

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Progress Report
    8. Frontispiece
    9. Communications
    10. Full Papers
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      Tissue Engineering: Three-Dimensional Human Tissue Chips Fabricated by Rapid and Automatic Inkjet Cell Printing (Adv. Healthcare Mater. 4/2013) (page 533)

      Michiya Matsusaki, Kayo Sakaue, Koji Kadowaki and Mitsuru Akashi

      Version of Record online: 5 APR 2013 | DOI: 10.1002/adhm.201370023

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      Rapid and automatic tissue engineering technology for 3D-human tissue chips consisting of over 400 simplified microtissues is described by Mitsuru Akashi and co-workers on page 534. The 3D-liver micro-arrays consisting of hepatocytes and endothelial cells are prepared by combination of hierarchical cell manipulation and inkjet cell printing technologies. The 3D-human tissue chips will be useful as an innovative technology for pharmaceutical assays.

  8. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Progress Report
    8. Frontispiece
    9. Communications
    10. Full Papers
    1. Three-Dimensional Human Tissue Chips Fabricated by Rapid and Automatic Inkjet Cell Printing (pages 534–539)

      Michiya Matsusaki, Kayo Sakaue, Koji Kadowaki and Mitsuru Akashi

      Version of Record online: 2 NOV 2012 | DOI: 10.1002/adhm.201200299

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      Rapid and automatic development of three-dimensional (3D) human micro-tissue chips which integrate over 400 micro-arrays of simplified multilayered structures is carried out using inkjet printing technology. Comprehensive high-throughput assays of liver functions using the simplified 3D liver structures revealed highest functions of a sandwich structure of endothelial cells and hepatocytes. These 3D-human tissue chips may enable “total-human tissue models” for tailor-made drug screening.

    2. Top-Down Fabrication of Polyelectrolyte-Thermoplastic Hybrid Microparticles for Unidirectional Drug Delivery to Single Cells (pages 540–545)

      Peipei Zhang, Yingru Liu, Junfei Xia, Zhibin Wang, Brett Kirkland and Jingjiao Guan

      Version of Record online: 23 OCT 2012 | DOI: 10.1002/adhm.201200200

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      This manuscript describes an inexpensive and versatile top-down method to produce microparticles that integrate both thermoplastics and polyelectrolytes with a unique dot-on-pad structure. These particles may allow in vivo unidirectional drug delivery to single cells.

    3. Nano- to Macroscale Remodeling of Functional Tissue-Engineered Bone (pages 546–551)

      Maria Ann Woodruff, Claudia Lange, Fulin Chen, Peter Fratzl and Dietmar Werner Hutmacher

      Version of Record online: 8 NOV 2012 | DOI: 10.1002/adhm.201200289

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      A higher degree of mineralization is found within scaffold groups implanted with cells compared to scaffold alone, demonstrating greater bone regenerative potential of cell-scaffold constructs Tissue engineered bone analysed using ESEM and SAXS demonstrates bone formation within the scaffold to be preferentially aligned around the scaffold struts. The mineral particles are not shown to orientate around the osteons within the native bone.

    4. Image-Predicated Sorting of Adherent Cells Using Photopatterned Hydrogels (pages 552–556)

      Joseph Kovac, Ylaine Gerardin and Joel Voldman

      Version of Record online: 1 NOV 2012 | DOI: 10.1002/adhm.201200196

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      Using photopatterned hydrogels and selective cell encapsulation, populations of adherent cells are examined using microscopy and sorted into viable sub-populations predicated on their imaged phenotypes. The inexpensive method utilizes commercial reagents and equipment available in many labs, making image-predicated cell sorting an accessible technique for a large number of individual labs.

    5. Chitosan Scaffolds with Unidirectional Microtubular Pores for Large Skeletal Myotube Generation (pages 557–561)

      Soumen Jana, Ashleigh Cooper and Miqin Zhang

      Version of Record online: 22 NOV 2012 | DOI: 10.1002/adhm.201200177

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      3D, uniaxially aligned, microtubular, porous chitosan scaffolds prepared via directional freeze-drying support the formation of large anisotropic myotubes. Myotubes of ∼550 μm long and ∼50 μm diameter are grown in the scaffolds after two weeks of culture. Porous chitosan scaffolds of varying pore architectures and mechanical properties can be readily produced using this fabrication process for engineering various anisotropic tissues.

    6. Platinum (IV) Pro-Drug Conjugated NaYF4:Yb3+/Er3+ Nanoparticles for Targeted Drug Delivery and Up-Conversion Cell Imaging (pages 562–567)

      Yunlu Dai, Xiaojiao Kang, Dongmei Yang, Xuejiao Li, Xiao Zhang, Chunxia Li, Zhiyao Hou, Ziyong Cheng, Ping'an Ma and Jun Lin

      Version of Record online: 2 NOV 2012 | DOI: 10.1002/adhm.201200234

      Thumbnail image of graphical abstract

      A folic acid targeted anticancer drug delivery system based on Pt (IV) complexes pro-drug conjugated up- conversion NaYF4:Yb3+/Er3+ nanoparticles has been developed. The platinum (IV) complexes as pro-drugs can exhibit anti-cancer activities when the platinum (IV) complexes are reduced to platinum (II) in the intracellular environment. Meanwhile, the drug delivery system can be used as a luminescent probe for up-conversion cell imaging.

  9. Full Papers

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Progress Report
    8. Frontispiece
    9. Communications
    10. Full Papers
    1. Biocompatibility Evaluation of Ionic- and Photo-Crosslinked Methacrylated Gellan Gum Hydrogels: In Vitro and In Vivo Study (pages 568–575)

      Joana Silva-Correia, Barbara Zavan, Vincenzo Vindigni, Tiago H. Silva, Joaquim M. Oliveira, Giovanni Abatangelo and Rui L. Reis

      Version of Record online: 2 NOV 2012 | DOI: 10.1002/adhm.201200256

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      Ionic- and photo-crosslinked methacrylated gellan gum hydrogels present promising physicochemical and biological properties for tissue engineering of nucleus pulposus. In vitro studies demonstrate the stability and encapsulation efficiency of the hydrogels with L929 cell line and primary human intervertebral disc cells. The biomaterials are able to sustain cell viability up to 21 days of culturing. The hydrogels are well-tolerated and non-toxic in vivo as shown by rat implantation.

    2. Optically Traceable Solid Lipid Nanoparticles Loaded with siRNA and Paclitaxel for Synergistic Chemotherapy with In situ Imaging (pages 576–584)

      Ki Hyun Bae, Jeong Yu Lee, Soo Hyeon Lee, Tae Gwan Park and Yoon Sung Nam

      Version of Record online: 26 NOV 2012 | DOI: 10.1002/adhm.201200338

      Thumbnail image of graphical abstract

      Low-density lipoprotein–mimetic solid lipid nanoparticles loaded with paclitaxel, siRNA, and quantum dots for synergistic combination therapy with in situ fluorescence monitoring are developed. The SLNs exhibit no significant cytotoxicity, and the simultaneous delivery of paclitaxel and Bcl-2 siRNA synergistically promotes the apoptotic death of human lung carcinoma cells by activating caspase-mediated pathways.

    3. Surface Bound Amine Functional Group Density Influences Embryonic Stem Cell Maintenance (pages 585–590)

      Frances Harding, Renee Goreham, Robert Short, Krasimir Vasilev and Nicolas H. Voelcker

      Version of Record online: 2 NOV 2012 | DOI: 10.1002/adhm.201200119

      Thumbnail image of graphical abstract

      A surface chemistry gradient reveals the sensitivity of embryonic stem cell behavior to amine functional group density on the underlying substrate. On a single surface, a range of octadiene/allylamine plasma co-polymer ratios are screened for support of cell attachment and stem cell marker expression. Optimal surface chemistry conditions are able to partly override differentiation induced by cytoskeletal disruption.

    4. Redox Cycling for Passive Modification of Polypyrrole Surface Properties: Effects on Cell Adhesion and Proliferation (pages 591–598)

      Kartik M. Sivaraman, Berna Özkale, Olgaç Ergeneman, Tessa Lühmann, Giuseppino Fortunato, Muhammad Arif Zeeshan, Bradley J. Nelson and Salvador Pané

      Version of Record online: 29 NOV 2012 | DOI: 10.1002/adhm.201200282

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      Biofouling refers to the adverse impact of adsorption and adhesion of biological entities like proteins and cells onto devices implanted inside the human body. In this work, the synthesis and the electrochemical modification of poly(pyrrole) to reduce biofouling is studied. When poly(pyrrole) is cathodically doped with sodium ions, cells do not adhere on the surface due to an increase of hydrophilicity.

    5. Membrane-Directed High Bactericidal Activity of (Gold Nanoparticle)–Polythiophene Composite for Niche Applications Against Pathogenic Bacteria (pages 599–606)

      Manab Deb Adhikari, Sudeep Goswami, Biswa Ranjan Panda, Arun Chattopadhyay and Aiyagari Ramesh

      Version of Record online: 22 NOV 2012 | DOI: 10.1002/adhm.201200278

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      (Gold nanoparticle)–polythiophene composite causes extensive membrane disruption and enables potential therapeutic interventions to counter the outer membrane barrier and adaptive mechanisms of pathogenic bacteria.

    6. Improved Triclosan Delivery by a Novel Silica-Based Nanocomposite (pages 607–619)

      Igor Makarovsky, Jonathan Lellouche, Jean-Paul Lellouche and Ehud Banin

      Version of Record online: 30 OCT 2012 | DOI: 10.1002/adhm.201200275

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      The design, synthesis, and full characterization of covalently-linked, triclosan NPs, coated with a polyaminated shell (NH2-T-SNPs) are reported herein. The biological mechanism of action of these novel NPs is elucidated via various techniques. NH2-T-SNPs are found to be potently bactericidal with no detectable activation time against E. coli and S. aureus and no human cytotoxicity.

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