Advanced Healthcare Materials

Cover image for Vol. 2 Issue 5

May, 2013

Volume 2, Issue 5

Pages 625–763

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Correction
    8. Review
    9. Communications
    10. Full Papers
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      Biocomposites: Silicon Micro- and Nanofabrication for Medicine (Adv. Healthcare Mater. 5/2013) (page 625)

      Daniel Fine, Alessandro Grattoni, Randy Goodall, Shyam S. Bansal, Ciro Chiappini, Sharath Hosali, Anne L. van de Ven, Srimeenkashi Srinivasan, Xuewu Liu, Biana Godin, Louis Brousseau III, Iman K. Yazdi, Joseph Fernandez-Moure, Ennio Tasciotti, Hung-Jen Wu, Ye Hu, Steve Klemm and Mauro Ferrari

      Version of Record online: 2 MAY 2013 | DOI: 10.1002/adhm.201370024

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      Silicon micro- and nanofabrication are used to create innovative biomedical technologies and provide a suitable means to support rapid clinical translation. The review on page 632 by Alessandro Grattoni and co-workers covers a broad spectrum of silicon nanosystems ranging from diagnostics to therapeutics.

  2. Inside Front Cover

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Correction
    8. Review
    9. Communications
    10. Full Papers
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      Drug Delivery: Antibody-Functionalized Porous Silicon Nanoparticles for Vectorization of Hydrophobic Drugs (Adv. Healthcare Mater. 5/2013) (page 626)

      Emilie Secret, Kevin Smith, Valentina Dubljevic, Eli Moore, Peter Macardle, Bahman Delalat, Mary-Louise Rogers, Terrance G. Johns, Jean-Olivier Durand, Frédérique Cunin and Nicolas H. Voelcker

      Version of Record online: 2 MAY 2013 | DOI: 10.1002/adhm.201370025

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      Biodegradable porous silicon nanoparticles (pSiNP) functionalized with cancer cell targeting antibodies and loaded with the hydrophobic anti-cancer drug camptothecin are developed by Nicolas H. Voelcker, Frédérique Cunin, and co-workers on page 718. High targeting and killing efficiency is demonstrated in vitro on three types of cancer cells: neuroblastoma, glioblastoma and lymphoma cells.

  3. Back Cover

    1. Top of page
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    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Correction
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      Cell Delivery: Core–Shell Hydrogel Microcapsules for Improved Islets Encapsulation (Adv. Healthcare Mater. 5/2013) (page 768)

      Minglin Ma, Alan Chiu, Gaurav Sahay, Joshua C. Doloff, Nimit Dholakia, Raj Thakrar, Joshua Cohen, Arturo Vegas, Delai Chen, Kaitlin M. Bratlie, Tram Dang, Roger L. York, Jennifer Hollister-Lock, Gordon C. Weir and Daniel G. Anderson

      Version of Record online: 2 MAY 2013 | DOI: 10.1002/adhm.201370026

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      Islets encapsulation is a promising approach for the treatment of Type I diabetes. On page 667, Daniel G. Anderson and co-workers report a novel design of microcapsules with core–shell structures using two-fluid co-axial electro-jetting. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.

  4. Masthead

    1. Top of page
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      Masthead: (Adv. Healthcare Mater. 5/2013)

      Version of Record online: 2 MAY 2013 | DOI: 10.1002/adhm.201370027

  5. Contents

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Correction
    8. Review
    9. Communications
    10. Full Papers
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  6. Correction

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
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      Correction: Self-assembly of Cytotoxic Peptide Amphiphiles into Supramolecular Membranes for Cancer Therapy (page 631)

      R. Helen Zha, Shantanu Sur and Samuel I. Stupp

      Version of Record online: 2 MAY 2013 | DOI: 10.1002/adhm.201390000

      This article corrects:

      Self-assembly of Cytotoxic Peptide Amphiphiles into Supramolecular Membranes for Cancer Therapy

      Vol. 2, Issue 1, 126–133, Version of Record online: 31 JUL 2012

  7. Review

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Correction
    8. Review
    9. Communications
    10. Full Papers
    1. Silicon Micro- and Nanofabrication for Medicine (pages 632–666)

      Daniel Fine, Alessandro Grattoni, Randy Goodall, Shyam S. Bansal, Ciro Chiappini, Sharath Hosali, Anne L. van de Ven, Srimeenkashi Srinivasan, Xuewu Liu, Biana Godin, Louis Brousseau III, Iman K. Yazdi, Joseph Fernandez-Moure, Ennio Tasciotti, Hung-Jen Wu, Ye Hu, Steve Klemm and Mauro Ferrari

      Version of Record online: 15 APR 2013 | DOI: 10.1002/adhm.201200214

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      The precision of silicon micro- and nanofabrication is used to create a range of innovative biomedical technologies. This review covers several of these technologies, including nanochannel implants, embedded vectors, nanowires, biocomposite porous silicon(pSi), and porous silica chips. The materials, silicon and its dielectrics, are produced using the high-throughput techniques ubiquitous within the semiconductor industry, with defined nanoscale features that could lead to rapid clinical translation.

  8. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Correction
    8. Review
    9. Communications
    10. Full Papers
    1. Core–Shell Hydrogel Microcapsules for Improved Islets Encapsulation (pages 667–672)

      Minglin Ma, Alan Chiu, Gaurav Sahay, Joshua C. Doloff, Nimit Dholakia, Raj Thakrar, Joshua Cohen, Arturo Vegas, Delai Chen, Kaitlin M. Bratlie, Tram Dang, Roger L. York, Jennifer Hollister-Lock, Gordon C. Weir and Daniel G. Anderson

      Version of Record online: 3 DEC 2012 | DOI: 10.1002/adhm.201200341

      Thumbnail image of graphical abstract

      Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core–shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.

    2. Assembly of Discrete Collagen–Chitosan Microenvironments into Multiphase Tissue Constructs (pages 673–677)

      David J. Caldwell, Rameshwar R. Rao and Jan P. Stegemann

      Version of Record online: 26 NOV 2012 | DOI: 10.1002/adhm.201200346

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      Modular assembly of protein–polysaccharide microenvironments into 3D macroscale tissue constructs is reported. Rapid and simple centrifugation and vacuum molding methods are used to create cohesive multiphase constructs with prescribed geometries. Human fibroblasts are shown to survive in the microenvironments and in the macroscale constructs. Control of the spatial organization in engineered tissues is a key to recreating the complex tissue architectures needed for regenerative therapies.

    3. Simvastatin-Loaded β-TCP Drug Delivery System Induces Bone Formation and Prevents Rhabdomyolysis in OVX Mice (pages 678–681)

      Joshua Chou, Tomoko Ito, Makoto Otsuka, Besim Ben-Nissan and Bruce Milthorpe

      Version of Record online: 26 NOV 2012 | DOI: 10.1002/adhm.201200342

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      Bone formation and regeneration is a prolonged process that requires a slow drug release system to assist in the long-term recovery. A drug-delivery system is developed that allows for the controlled release of simvastin, without exhibiting the side effects associated with high concentrations of simvastatin, and is still capable of inducing constant bone formation.

    4. Morphology Controlled Porous Calcium Phosphate Nanoplates and Nanorods with Enhanced Protein Loading and Release Functionality (pages 682–686)

      Philip James Thomas Reardon, Jie Huang and Junwang Tang

      Version of Record online: 13 FEB 2013 | DOI: 10.1002/adhm.201200276

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      Calcium phosphate nanoplates and nanorods with controllable pores and enhanced protein loading and tuneable release characteristics are first synthesized without the use of any toxic surfactants by an energy efficient microwave assisted chemical process, hence demonstrating their viability as a tool for controllable drug delivery in biomaterial systems.

    5. Reducing Bacterial Colonization of 3-D Nanofiber Cell Scaffolds by Hierarchical Assembly of Microgels and an Antimicrobial Peptide (pages 687–691)

      Qichen Wang, Xiaojun Yu and Matthew Libera

      Version of Record online: 21 NOV 2012 | DOI: 10.1002/adhm.201200306

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      The hierarchical electrostatic deposition of anionic microgels and a cationic oligopeptide throughout a PCL-chitosan nanofiber scaffold inhibits S. epidermidis colonization of the scaffold interior while promoting osteoblast adhesion, spreading, and proliferation on the scaffold surface.

  9. Full Papers

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Correction
    8. Review
    9. Communications
    10. Full Papers
    1. Physicochemical, Cytotoxic, and Dermal Release Features of a Novel Cationic Liposome Nanocarrier (pages 692–701)

      Maura Carboni, Angela M. Falchi, Sandrina Lampis, Chiara Sinico, Maria L. Manca, Judith Schmidt, Yeshayahu Talmon, Sergio Murgia and Maura Monduzzi

      Version of Record online: 2 NOV 2012 | DOI: 10.1002/adhm.201200302

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      Liposomes based on monoolein and lauroylcholine chloride are taken up by 3T3 fibroblasts. Liposome treatment induces lipid droplets formation as shown by Nile Red staining. Green fluorescent lipid droplets become intense 4 h after the treatment. Nuclear staining with Hoechst 33258 revealed nuclear morphology of viable cells.

    2. Nanospiderwebs: Artificial 3D Extracellular Matrix from Nanofibers by Novel Clinical Grade Electrospinning for Stem Cell Delivery (pages 702–717)

      Mohammad A. Alamein, Qin Liu, Sebastien Stephens, Stuart Skabo, Frauke Warnke, Robert Bourke, Peter Heiner and Patrick H. Warnke

      Version of Record online: 1 NOV 2012 | DOI: 10.1002/adhm.201200287

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      A novel electrospinning process for engineering three-dimensional nanofi-brous extracellular matrixes (NFECMs) is initiated using a NanoSpider machine. Under clinical grade goodmanufacturing-practice-like conditions, several NF-ECMs are designed in a controlled manner to yield highly uniform fibers with sub-micrometer dimensions, favourable biomechanical properties and intrinsic cytobiocompatility. This permits both the proliferation and differentiation of human mesenchymal stem cells when provided appropriate biological cues.

    3. Antibody-Functionalized Porous Silicon Nanoparticles for Vectorization of Hydrophobic Drugs (pages 718–727)

      Emilie Secret, Kevin Smith, Valentina Dubljevic, Eli Moore, Peter Macardle, Bahman Delalat, Mary-Louise Rogers, Terrance G. Johns, Jean-Olivier Durand, Frédérique Cunin and Nicolas H. Voelcker

      Version of Record online: 30 NOV 2012 | DOI: 10.1002/adhm.201200335

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      Mesoporous silicon nanoparticles that are able to specifically target and deliver hydrophobic anti-cancer drugs to cancer cells are developed. Porous silicon nanoparticles are functionalized with antibodies in a controlled way, in order to efficiently target cancer cells expressing the corresponding receptor. High targeting and killing efficiency is demonstrated in vitro on three types on cancer cells: neuroblastoma, glioblastoma and lymphoma cells.

    4. In Vitro Biocompatibility of Multiwalled Carbon Nanotubes with Sensory Neurons (pages 728–735)

      Karen M. Gladwin, Raymond L. D. Whitby, Sergey V. Mikhalovsky, Paul Tomlins and Jimi Adu

      Version of Record online: 8 NOV 2012 | DOI: 10.1002/adhm.201200233

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      Multiwalled carbon nanotubes (MWCNTs) have been reported as a potential material for application in neurobiological scaffolds. However, our results demonstrate that compared to laminin, a basement membrane protein found in axon pathways, MWCNTs provide an inferior substrate for the growth of postnatal dorsal root ganglia neurons. These findings suggest that although neurons will grow on MWCNT substrates, these substrates require surface modification to support optimal neurite outgrowth.

    5. An Anti-PSMA Bivalent Immunotoxin Exhibits Specificity and Efficacy for Prostate Cancer Imaging and Therapy (pages 736–744)

      Fayun Zhang, Liang Shan, Yuanyi Liu, David Neville, Jung-Hee Woo, Yue Chen, Alexandru Korotcov, Stephen Lin, Sophia Huang, Rajagopalan Sridhar, Wei Liang and Paul C. Wang

      Version of Record online: 22 NOV 2012 | DOI: 10.1002/adhm.201200254

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      An immunotoxin is produced which is effective for targeted killing and selective imaging of PSMA-expressing prostate cancer cells grown in vitro and in vivo. This immunotoxin is without effect on prostate cancer cells that are deficient in PSMA expression and may find theranostic use in the clinic for selectively treating tumors that overexpress PSMA.

    6. Mechanically Robust, Negative-Swelling, Mussel-Inspired Tissue Adhesives (pages 745–755)

      Devin G. Barrett, Grace G. Bushnell and Phillip B. Messersmith

      Version of Record online: 23 NOV 2012 | DOI: 10.1002/adhm.201200316

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      Adhesive hydrogels that negatively swell at physiological temperature are presented. By combining mussel-mimetic chemistry and the thermosensitive nature of poly(ethylene oxide)-poly(propylene oxide) copolymers, novel materials are designed that are suitable as medical sealants and adhesives.

    7. Near-Infrared Fluorescent Silica-Coated Gold Nanoparticle Clusters for X-Ray Computed Tomography/Optical Dual Modal Imaging of the Lymphatic System (pages 756–763)

      Koichiro Hayashi, Michihiro Nakamura and Kazunori Ishimura

      Version of Record online: 26 NOV 2012 | DOI: 10.1002/adhm.201200238

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      Computed tomography/fluorescence dual modal imaging using near-infrared fluorescent silica-coated gold nanoparticle clusters provides anatomical information, including the location and size of lymph nodes (LNs) and lymphatic vessels (LVs) for designing a surgery plan. It can also provide intraoperative visualization of LNs and LVs to facilitate the operation.

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