Advanced Healthcare Materials

Cover image for Vol. 2 Issue 6

June, 2013

Volume 2, Issue 6

Pages 769–915

  1. Cover Picture

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      Sensors: Optical Nanosphere Sensor Based on Shell-By-Shell Fabrication for Removal of Toxic Metals from Human Blood (Adv. Healthcare Mater. 6/2013) (page 769)

      S. A. El-Safty, S. Abdellatef, M. Ismael and A. Shahat

      Version of Record online: 13 JUN 2013 | DOI: 10.1002/adhm.201370029

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      Sherif El-Safty and co-workers report on page 854 a novel, pH-dependent sensor design based on naked-eye detection for the removal of toxic metal ions from drinking water and human blood. The inexpensive, simple-to-use, and multi-ion sensing design shows efficient reproducibility, longevity, selectivity, and signal stability. This unique hierarchical sensor has potential for the rapid screening of blood lead levels so that the effects of lead toxicity can be avoided.

  2. Inside Front Cover

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      Cell Targeting: Transferrin-Mediated Rapid Targeting, Isolation, and Detection of Circulating Tumor Cells by Multifunctional Magneto-Dendritic Nanosystem (Adv. Healthcare Mater. 6/2013) (page 770)

      Shashwat S. Banerjee, Archana Jalota-Badhwar, Sneha D. Satavalekar, Sujit G. Bhansali, Naval D. Aher, Russel R. Mascarenhas, Debjani Paul, Somesh Sharma and Jayant J. Khandare

      Version of Record online: 13 JUN 2013 | DOI: 10.1002/adhm.201370030

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      A multicomponent magneto-dendritic nanosystem (MDNS) is designed for rapid tumor cell targeting, isolation, and high-resolution imaging by a facile bioconjugation approach. Jayant J. Khandare and co-workers show on page 800 that the MDNS system is capable of capturing circulating tumors cells rapidly from the mixture of peripheral blood cells. This approach is envisioned for the early diagnosis of metastatic cancer.

  3. Back Cover

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      Hydrogels: Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion (Adv. Healthcare Mater. 6/2013) (page 920)

      Yoojin Shin, Hyunju Kim, Sewoon Han, Jihee Won, Hyo Eun Jeong, Eun-Sook Lee, Roger D. Kamm, Jae-Hong Kim and Seok Chung

      Version of Record online: 13 JUN 2013 | DOI: 10.1002/adhm.201370031

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      Plasticity and reciprocity of breast cancer cells to various extracellular matrices (ECMs) are three-dimensionally analyzed in a quantitative way using a novel and powerful microfluidic in vitro platform. The metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change are demonstrated. Further details can be found in the article by Seok Chung, Jae-Hong Kim, and co-workers on page 790.

  4. Masthead

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      Masthead: (Adv. Healthcare Mater. 6/2013)

      Version of Record online: 13 JUN 2013 | DOI: 10.1002/adhm.201370032

  5. Contents

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    5. Masthead
    6. Contents
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  6. Communications

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    1. Direct Plotting of Three-Dimensional Hollow Fiber Scaffolds Based on Concentrated Alginate Pastes for Tissue Engineering (pages 777–783)

      Yongxiang Luo, Anja Lode and Michael Gelinsky

      Version of Record online: 26 NOV 2012 | DOI: 10.1002/adhm.201200303

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      Porous scaffolds for tissue engineering applications consisting of hollow alginate fibers are presented. They are prepared using self-made shell/core nozzles and a 3D plotting device. Such materials open up the possibility to generate biodegradable tissue constructs with a preformed vascular system or can act as matrices for engineering of complex organs or 3D tissue models.

    2. Combination of Anti-Biofouling and Ion-Interaction by Click Chemistry for Endotoxin Selective Removal from Protein Solution (pages 784–789)

      Jinshan Guo, Fanbo Meng, Xiabin Jing and Yubin Huang

      Version of Record online: 26 NOV 2012 | DOI: 10.1002/adhm.201200157

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      A successful combination of anti-biofouling and ion-interaction for endotoxin (ET) selective removal from protein solutions is realized via the immobilization of two ordinary polymers, PEG and PLL, which have protein resistance and endotoxin adsorption properties, respectively, together onto azide-functional polystyrene (PS-N3) microspheres (MSs) using a surface click reaction. Toxic copper ions residu is successfully minimized by the addition of 2,2′-bipyridine (BiPy).

    3. Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion (pages 790–794)

      Yoojin Shin, Hyunju Kim, Sewoon Han, Jihee Won, Hyo Eun Jeong, Eun-Sook Lee, Roger D. Kamm, Jae-Hong Kim and Seok Chung

      Version of Record online: 26 NOV 2012 | DOI: 10.1002/adhm.201200320

      Thumbnail image of graphical abstract

      Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs.

    4. One-Step Photo Synthesis of Protein–Drug Nanoassemblies for Drug Delivery (pages 795–799)

      Jinbing Xie, Yi Cao, Mao Xia, Xiang Gao, Meng Qin, Jiwu Wei and Wei Wang

      Version of Record online: 7 JAN 2013 | DOI: 10.1002/adhm.201200285

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      Upon controlled UV illumination, disulfide bonds in bovine α-lactalbumin (BLA) are selectively broken, leading to self-assembly of the BLA and doxorubicin (DOX) molecules into nanoparticles via hydrophobic interactions and intermolecular disulfide bonds. Such protein–drug nanoparticles have synergistic anticancer activity in vitro and tumor-homing specificity in vivo, which are of great potential for systemic drug delivery in cancer therapy.

    5. Transferrin-Mediated Rapid Targeting, Isolation, and Detection of Circulating Tumor Cells by Multifunctional Magneto-Dendritic Nanosystem (pages 800–805)

      Shashwat S. Banerjee, Archana Jalota-Badhwar, Sneha D. Satavalekar, Sujit G. Bhansali, Naval D. Aher, Russel R. Mascarenhas, Debjani Paul, Somesh Sharma and Jayant J. Khandare

      Version of Record online: 1 NOV 2012 | DOI: 10.1002/adhm.201200164

      Thumbnail image of graphical abstract

      A multicomponent magneto-dendritic nanosystem (MDNS) is designed for rapid tumor cell targeting, isolation, and high-resolution imaging by a facile bioconjugation approach. The highly efficient and rapid-acting MDNS provides a convenient platform for simultaneous isolation and high-resolution imaging of tumor cells, potentially leading towards an early diagnosis of cancer.

    6. Electroresponsive Polymer–Carbon Nanotube Hydrogel Hybrids for Pulsatile Drug Delivery In Vivo (pages 806–811)

      Ania Servant, Laura Methven, Rhodri P. Williams and Kostas Kostarelos

      Version of Record online: 26 NOV 2012 | DOI: 10.1002/adhm.201200193

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      Drug release triggered by an external non-invasive stimulus is of great interest for the development of new drug delivery systems. The preparation of an electroresponsive multiwalled carbon nanotube/poly(methylacrylic acid) (MWNT/PMAA)-based hybrid material is reported. The hydrogel hybrids achieve a controlled drug release upon the ON/OFF application of an electric field, giving rise to in vitro and in vivo pulsatile release profiles.

    7. Tower Microneedle Via Reverse Drawing Lithography for Innocuous Intravitreal Drug Delivery (pages 812–816)

      Chang Yeol Lee, Kwang Lee, Yong Sung You, Sung Ho Lee and Hyungil Jung

      Version of Record online: 3 DEC 2012 | DOI: 10.1002/adhm.201200239

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      The “tower microneedle” (TM) via reverse drawing lithography for intravitreal injection by fabricating a long hollow microneedle on the blunt hypodermic needle: The hollow hole between the microneedle and hypodermic needle is aligned concentrically, and fifteen degree bevel angle is introduced to TM by laser cutting to achieve intravitreal injection with minimal damage to eye tissue.

    8. Slicing, Stacking and Rolling: Fabrication of Nanostructured Collagen Constructs from Tendon Sections (pages 817–821)

      Kyle A. Alberti and Qiaobing Xu

      Version of Record online: 12 DEC 2012 | DOI: 10.1002/adhm.201200319

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      A novel method for fabricating both multilayer stacked 2D and 3D tubular constructs composed of sheets of aligned collagen fibers is described. These structures are created by decellularizing native tendon and sectioning the material into thin sheets using a cryo-microtome. This fabrication method preserves the collagens natural strength as well as the fiber structure which would aid in directing aligned cell growth.

    9. A Polymer–(Tandem Drugs) Conjugate for Enhanced Cancer Treatment (pages 822–827)

      Dongfang Zhou, Haihua Xiao, Fanbo Meng, Xiaoyuan Li, Yuxin Li, Xiabin Jing and Yubin Huang

      Version of Record online: 7 JAN 2013 | DOI: 10.1002/adhm.201200385

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      A novel strategy for combination chemotherapy (platinum and demethylcantharidin) via a polymer–(tandem drugs) conjugate for enhanced cancer treatment is demonstrated. Cisplatin can be released inside cell by reduction to attack DNA, while DMC will be hydrolyzed subsequently to block DNA-damage-induced defense mechanisms by serine/threonine phosphatase PP2A inhibition. Synergistic effect of the polymer–(tandem drugs) conjugate causes complete suppression of H22 liver tumor xenografts without recurrence.

  7. Frontispiece

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Communications
    8. Frontispiece
    9. Full Papers
    10. Research News
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      Nanoparticles: Endotoxin Removal by Magnetic Separation-Based Blood Purification (Adv. Healthcare Mater. 6/2013) (page 828)

      Inge K. Herrmann, Martin Urner, Samuel Graf, Christoph M. Schumacher, Birgit Roth-Z'graggen, Melanie Hasler, Wendelin J. Stark and Beatrice Beck-Schimmer

      Version of Record online: 13 JUN 2013 | DOI: 10.1002/adhm.201370034

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      Magnetic separation-based blood purification enables rapid and selective removal of endotoxin and bacteria from human whole blood. Functional assays assessing key steps in host defense against bacteria show an attenuated inflammatory response in purified samples and less chemotactic activity. Beatrice Beck-Schimmer and co-workers introduce on page 829 this promising new approach for future sepsis treatment.

  8. Full Papers

    1. Top of page
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    1. Endotoxin Removal by Magnetic Separation-Based Blood Purification (pages 829–835)

      Inge K. Herrmann, Martin Urner, Samuel Graf, Christoph M. Schumacher, Birgit Roth-Z'graggen, Melanie Hasler, Wendelin J. Stark and Beatrice Beck-Schimmer

      Version of Record online: 6 DEC 2012 | DOI: 10.1002/adhm.201200358

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      Playing a central role in the development of gram-negative sepsis, endotoxins are attractive therapeutic targets. However, their direct removal from protein-rich fluids remains challenging. This article presents a magnetic separation-based approach using polymyxin B-functionalized metal nanomagnets to eliminate endotoxin from human blood in vitro. Functional assays show an attenuated inflammatory response from human endothelial cells and less chemotactic activity in purified samples.

    2. Mesoporous Europo-Gadolinosilicate Nanoparticles as Bimodal Medical Imaging Agents and a Potential Theranostic Platform (pages 836–845)

      Nicholas M. K. Tse, Danielle F. Kennedy, Nigel Kirby, Bradford A. Moffat, Benjamin W. Muir, Rachel A. Caruso and Calum J. Drummond

      Version of Record online: 7 JAN 2013 | DOI: 10.1002/adhm.201200262

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      Gadolinium and europium ions are incorporated into a mesoporous silicate framework; a potential theranostic platform to achieve bimodal medical imaging capability. These nanomaterials outperform the commercially available T1 MRI contrast agent, Omniscan with the added benefit of exhibiting photoluminescence properties.

    3. Gradient-Regulated Hydrogel for Interface Tissue Engineering: Steering Simultaneous Osteo/Chondrogenesis of Stem Cells on a Chip (pages 846–853)

      Xuetao Shi, Jianhua Zhou, Yihua Zhao, Lei Li and Hongkai Wu

      Version of Record online: 28 NOV 2012 | DOI: 10.1002/adhm.201200333

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      A stem cell-encapsulated hydrogel laden microfluidic device with the function of gradient generation that can steer distinct specialized differentiation of stem cells on the hydrogel slab is developed in this study. This microfluidic model can be used to construct the interfacial tissues such as articular cartilage and relevant osteointegration of the cartilage graft.

    4. Optical Nanosphere Sensor Based on Shell-By-Shell Fabrication for Removal of Toxic Metals from Human Blood (pages 854–862)

      S. A. El-Safty, S. Abdellatef, M. Ismael and A. Shahat

      Version of Record online: 11 JAN 2013 | DOI: 10.1002/adhm.201200326

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      An optical nanosphere sensor is developed for the removal of toxic metals from drinking water and blood. The sensor design creates highly accessible, flexible, and fine-tuned surfaces, which make unique sensing/removal systems that are inexpensive, simple, and highly sensitive to multiple metal ions. The design exhibits potential counteractions and inhibitions toward toxic effects associated with elevated blood lead levels.

    5. Mesoporous Silica-Calcium Phosphate-Tuberculin Purified Protein Derivative Composites as an Effective Adjuvant for Cancer Immunotherapy (pages 863–871)

      Xia Li, Xiupeng Wang, Yu Sogo, Tadao Ohno, Kazuo Onuma and Atsuo Ito

      Version of Record online: 7 JAN 2013 | DOI: 10.1002/adhm.201200149

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      Mesoporous silica/calcium phosphate composite loaded with immunopotentiator tuberculin purified protein derivative (PPD-MS/CaP) as an effective adjuvant for cancer immunotherapy is synthesized. The adjuvant induces an enhanced activation of antigen-presenting cells, such as GM-CSF secretion by differentiated THP-1 cells. The adjuvant mixed with liquid-N2-treated tumor tissue effectively triggers anti-tumor immune response and greatly inhibits in vivo tumor growth.

    6. Integrated Bi-Layered Scaffold for Osteochondral Tissue Engineering (pages 872–883)

      Anna Galperin, Rachael A. Oldinski, Stephen J. Florczyk, James D. Bryers, Miqin Zhang and Buddy D. Ratner

      Version of Record online: 6 DEC 2012 | DOI: 10.1002/adhm.201200345

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      A degradable integrated bi-layered scaffold for osteochondral tissue engineering is fabricated. The ability of the scaffold to support in vitro simultaneous matrix deposition, adequate cell growth and cell differentiation of two distinct cell lineages, human mesenchymal stem cells and chondrocytes, in designated bone and cartilage layers of the scaffold, is demonstrated.

    7. A Core–Shell Albumin Copolymer Nanotransporter for High Capacity Loading and Two-Step Release of Doxorubicin with Enhanced Anti-Leukemia Activity (pages 884–894)

      Yuzhou Wu, Susann Ihme, Michaela Feuring-Buske, Seah Ling Kuan, Klaus Eisele, Markus Lamla, Yanran Wang, Christian Buske and Tanja Weil

      Version of Record online: 7 DEC 2012 | DOI: 10.1002/adhm.201200296

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      A human serum albumin derived core-shell DOX delivery system is prepared based on an innovative protein denaturing-backfolding strategy. This system possesses a considerable DOX loading capacity, a two-step controlled drug release mechanism, attractive biocompatibility and narrow size distribution inherited from the monodisperse albumin backbone, as well as fast cellular uptake and masking of HSA epitopes due to cationization and pegylation.

    8. Photocrosslinkable Kappa-Carrageenan Hydrogels for Tissue Engineering Applications (pages 895–907)

      Silvia M. Mihaila, Akhilesh K. Gaharwar, Rui L. Reis, Alexandra P. Marques, Manuela E. Gomes and Ali Khademhosseini

      Version of Record online: 27 DEC 2012 | DOI: 10.1002/adhm.201200317

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      Functionalization of kappa carrageenan by introducing photocrosslinkable moieties enables the formation of dual crosslinked hydrogels. The modification results in formation of highly porous hydrogel networks with tunable mechanical properties that can bear repetitive loading cycles without deformation. By micromolding approaches, fabrication of spatially controlled geometries renders the development of cell-patterned platforms for different biomedical and biotechnological applications.

  9. Research News

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Back Cover
    5. Masthead
    6. Contents
    7. Communications
    8. Frontispiece
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    10. Research News
    1. Current Progress in Reactive Oxygen Species (ROS)-Responsive Materials for Biomedical Applications (pages 908–915)

      Sue Hyun Lee, Mukesh K. Gupta, Jae Beum Bang, Hojae Bae and Hak-Joon Sung

      Version of Record online: 25 JAN 2013 | DOI: 10.1002/adhm.201200423

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      The recent development of reactive oxygen species (ROS)-responsive materials is inspired by numerous disease states, such as cancer and inflammation, involving the overproduction of ROS. ROS-responsive materials available today employ two general mechanisms: i) solubility switch and ii) degradation upon exposure to ROS. These materials can be used for drug and cell delivery to interact with the pathophysiological states more intelligently.

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