Bulk Manufacture of Concentrated Oxygen Gas-Filled Microparticles for Intravenous Oxygen Delivery (pages 1131–1141)
John N. Kheir, Brian D. Polizzotti, Lindsay M. Thomson, Daniel W. O'Connell, Katherine J. Black, Robert W. Lee, James N. Wilking, Adam C. Graham, David C. Bell and Francis X. McGowan
Article first published online: 8 MAR 2013 | DOI: 10.1002/adhm.201200350
Lipid-based oxygen microparticles have been described as a means to administer oxygen gas intravenously as a means to reverse systemic hypoxemia. This work describes the bulk manufacture of concentrated, gas-filled microparticles using a high shear homogenizer, creating microparticles which are stable at room temperature for 100 days. These microparticles transfer oxygen to human blood within seconds of contact in vitro, without signs of hemolysis or complement activation.