Advanced Healthcare Materials

Cover image for Vol. 2 Issue 9

September, 2013

Volume 2, Issue 9

Pages 1181–1293

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Full Papers
    1. You have free access to this content
      Drug Delivery: Targeted and pH-Responsive Delivery of Doxorubicin to Cancer Cells Using Multifunctional Dendrimer-Modified Multi-Walled Carbon Nanotubes (Adv. Healthcare Mater. 9/2013) (page 1181)

      Shihui Wen, Hui Liu, Hongdong Cai, Mingwu Shen and Xiangyang Shi

      Article first published online: 10 SEP 2013 | DOI: 10.1002/adhm.201370045

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      Xiangyang Shi and co-workers show on page 1267 that the unique combination of dendrimer chemistry and carbon nanotubes allows the generation of multifunctional nanodevices for high-payload encapsulation of a model anticancer drug doxorubicin with pH-responsive release behavior and targeting specificity, providing an efficient strategy for targeted cancer therapy.

  2. Inside Front Cover

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Full Papers
    1. You have free access to this content
      Superhydrophobic Materials: Triggered Drug Release from Superhydrophobic Meshes using High-Intensity Focused Ultrasound (Adv. Healthcare Mater. 9/2013) (page 1182)

      Stefan T. Yohe, Jonathan A. Kopechek, Tyrone M. Porter, Yolonda L. Colson and Mark W. Grinstaff

      Article first published online: 10 SEP 2013 | DOI: 10.1002/adhm.201370046

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      On page 1204, Mark W. Grinstaff and co-workers report the triggered release of drug from an electrospun superhydrophobic mesh using ultrasound, by displacing an entrapped air layer. The air layer within the superhydrophobic meshes is characterized using direct visualization and B-mode imaging. Drug-loaded superhydrophobic meshes are cytotoxic in an in vitro assay after ultrasound treatment.

  3. Masthead

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Full Papers
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      Masthead: (Adv. Healthcare Mater. 9/2013)

      Article first published online: 10 SEP 2013 | DOI: 10.1002/adhm.201370047

  4. Contents

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Full Papers
    1. You have free access to this content
      Contents: (Adv. Healthcare Mater. 9/2013) (pages 1183–1187)

      Article first published online: 10 SEP 2013 | DOI: 10.1002/adhm.201370048

  5. Review

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Full Papers
    1. Functional Morphometric Analysis in Cellular Behaviors: Shape and Size Matter (pages 1188–1197)

      Haiyang Yu, Kee Pah Lim, Sijing Xiong, Lay Poh Tan and Winston Shim

      Article first published online: 27 MAY 2013 | DOI: 10.1002/adhm.201300053

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      This is the first comprehensive review on common methodologies in morphological characterization of cellular systems. In this review, the underlying principles, assumptions, and limitations of morphological characterizations are discussed. The significance, challenges, and implications of quantitative morphometric characterization of cell shapes and sizes in cellular function are highlighted.

  6. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Full Papers
    1. Glucosamine-Conjugated Nanoparticles for the Separation of Insulin-Secreting Beta Cells (pages 1198–1203)

      Karthikeyan Narayanan, Alex W. H. Lin, Yuangang Zheng, Nandanan Erathodiyil, Andrew C. A. Wan and Jackie Y. Ying

      Article first published online: 8 MAR 2013 | DOI: 10.1002/adhm.201200479

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      A small molecule, glucosamine, is used as targeting moiety for insulin-secreting beta cell separation in artificial cell mixtures and tissue samples. The specificity of glucosamine allows it to be used in cell sorting applications. In addition, a thrombin-specific cleavable peptide was used as an intermediary to release nanoparticles from cell surfaces to facilitate cell attachment and proliferation.

    2. Triggered Drug Release from Superhydrophobic Meshes using High-Intensity Focused Ultrasound (pages 1204–1208)

      Stefan T. Yohe, Jonathan A. Kopechek, Tyrone M. Porter, Yolonda L. Colson and Mark W. Grinstaff

      Article first published online: 17 APR 2013 | DOI: 10.1002/adhm.201200381

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      Application of high-intensity focused ultrasound to drug-loaded superhydrophobic meshes affords triggered drug release by displacing an entrapped air layer. The air layer within the superhydrophobic meshes is characterized using direct visualization and B-mode imaging. Drug-loaded superhydrophobic meshes are cytotoxic in an in vitro assay after ultrasound treatment.

    3. Human Erythrocytes Covered with Magnetic Core–Shell Nanoparticles for Multimodal Imaging (pages 1209–1212)

      Mathieu Laurencin, Nithavong Cam, Thomas Georgelin, Olivier Clément, Gwennhael Autret, Jean-Michel Siaugue and Christine Ménager

      Article first published online: 9 APR 2013 | DOI: 10.1002/adhm.201200384

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      Surface functionalization of human red blood cells (hRBCs) with fluorescent and magnetic silica core-shell nanoparticles is used to design a carrier suitable for multimodal imaging with a long circulating time. The coated magnetic hRBCs show no hemolytic activity, while the advantage of the affinity of proteins for silica allows a further coating.

    4. Functional Living Biointerphases (pages 1213–1218)

      Anas Saadeddin, Aleixandre Rodrigo-Navarro, Vicente Monedero, Patricia Rico, David Moratal, María Luisa González-Martín, David Navarro, Andrés J. García and Manuel Salmerón-Sánchez

      Article first published online: 28 FEB 2013 | DOI: 10.1002/adhm.201200473

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      Lactococcus lactis is modified to express a fibronectin fragment (FNIII7-10) as a membrane protein. This interphase, based on a living system, can be further exploited to provide spatio-temporal factors to direct cell function at the material interface. This approach establishes a new paradigm in biomaterial surface functionalization for biomedical applications.

    5. Tunable Mechanical Properties of Ultrasmall Peptide Hydrogels by Crosslinking and Functionalization to Achieve the 3D Distribution of Cells (pages 1219–1223)

      Wei Yang Seow and Charlotte A. E. Hauser

      Article first published online: 12 MAR 2013 | DOI: 10.1002/adhm.201200463

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      A disulfide-crosslinked hydrogel made from ultrasmall peptides is introduced. Crosslinked gels are more elastic and better able to maintain shape integrity. Using facile chemistry, RGD (or other bioactive signals) can be conjugated onto the peptide fibers. Gels formed are biocompatible and support the three-dimensional distribution of cells.

    6. μHall Chip for Sensitive Detection of Bacteria (pages 1224–1228)

      David Issadore, Hyun Jung Chung, Jaehoon Chung, Ghyslain Budin, Ralph Weissleder and Hakho Lee

      Article first published online: 12 MAR 2013 | DOI: 10.1002/adhm.201200380

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      A microHall (μHall) sensor platform is developed to detect rare pathogens in unprocessed clinical samples. The system employes an array of μHall elements to accurately enumerate individual, magnetically tagged bacteria under flow conditions. It allows direct bacterial detection in unprocessed samples, which not only improves the overall throughput but also simplifies assay procedures.

  7. Full Papers

    1. Top of page
    2. Cover Picture
    3. Inside Front Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Full Papers
    1. Enhanced Osteogenesis by a Biomimic Pseudo-Periosteum-Involved Tissue Engineering Strategy (pages 1229–1235)

      Xuetao Shi, Song Chen, Yihua Zhao, Chen Lai and Hongkai Wu

      Article first published online: 12 MAR 2013 | DOI: 10.1002/adhm.201300012

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      A newly developed collagen based pseudo-periosteum that simulates the motif of native perisoteum has a strong influence on spatially alignment and proliferation of stem cells. Importantly, the pseudo-periosteum-covered porous scaffold significantly promotes osteogenesis when compared with the pseudo-periosteum-free scaffold, indicating the important potential of periosteum in bone remolding and healing.

    2. Multifunctional Albumin Nanoparticles As Combination Drug Carriers for Intra-Tumoral Chemotherapy (pages 1236–1245)

      Mingjie Cui, Dominik J. Naczynski, Margot Zevon, Craig K. Griffith, Larisa Sheihet, Izmarie Poventud-Fuentes, Suzie Chen, Charles M. Roth and Prabhas V. Moghe

      Article first published online: 12 MAR 2013 | DOI: 10.1002/adhm.201200467

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      Recombinant human albumin derived nanoparticles (ANPs) are engineered to overcome multiple barriers that challenge drug delivery and tumor chemotherapy. By integrating distinct technological features of nanoscale size variation, collagenase decoration, and modification with dual, complementary drugs (curcumin and riluzole), the ANPs can undergo enhanced intracellular uptake, penetrate deeper into solid tumor matrices, and exhibit significantly enhanced overall efficacy against melanoma in a tumor spheroid model.

    3. Assembled Microcapsules by Doxorubicin and Polysaccharide as High Effective Anticancer Drug Carriers (pages 1246–1251)

      Cuiling Du, Jie Zhao, Jinbo Fei, Yue Cui and Junbai Li

      Article first published online: 4 APR 2013 | DOI: 10.1002/adhm.201200414

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      Doxorubicin is used together with the modified polysaccharide as a wall material to fabricate microcapsules through electrostatic interaction and Schiff's base covalent bonding by a simple template method. Doxorubicin can be released responsively and sustainably from the capsules in the tumor microenvironment in vitro. The cell cytotoxicity experiments demonstrate that the doxorubicin-based microcapsules have high efficiency to kill cancer cells.

    4. A Light-Driven Anti-Cancer Dual-Therapeutic Cassette Enhances Solid Tumour Regression (pages 1252–1258)

      A Ra Kim, Seung Won Shin, Seung-Woo Cho, Joo Young Lee, Dong-Ik Kim and Soong Ho Um

      Article first published online: 14 MAR 2013 | DOI: 10.1002/adhm.201200471

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      A dual therapeutic cassette is presented composed of two distinct compartments that contain the combined nanostructures of (1) DNA and RNA as both anticancer container and target ligand and (2) gold nanocrystal as a localized heat inducer. This multimodular platform shows a powerful synergistic killing effect that results in prostate cancer regression both in vitro and in vivo.

    5. Graphene Oxide-Based Antibacterial Cotton Fabrics (pages 1259–1266)

      Jinming Zhao, Bo Deng, Min Lv, Jingye Li, Yujie Zhang, Haiqing Jiang, Cheng Peng, Jiang Li, Jiye Shi, Qing Huang and Chunhai Fan

      Article first published online: 11 MAR 2013 | DOI: 10.1002/adhm.201200437

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      Graphene oxide can be loaded on cotton fabrics via various ways, and such a composite shows high anti-bacterial properties with minimal skin irritation.

    6. Targeted and pH-Responsive Delivery of Doxorubicin to Cancer Cells Using Multifunctional Dendrimer-Modified Multi-Walled Carbon Nanotubes (pages 1267–1276)

      Shihui Wen, Hui Liu, Hongdong Cai, Mingwu Shen and Xiangyang Shi

      Article first published online: 28 FEB 2013 | DOI: 10.1002/adhm.201200389

      Thumbnail image of graphical abstract

      An effective targeted and pH-responsive drug delivery system: The unique combination of dendrimer chemistry and carbon nanotubes allows the generation of multifunctional nanodevices for high-payload encapsulation of a model anticancer drug doxorubicin with pH-responsive release behavior and targeting specificity, providing an efficient strategy for targeted cancer therapy.

    7. Unique Antimicrobial Effects of Platelet-Rich Plasma and Its Efficacy as a Prophylaxis to Prevent Implant-Associated Spinal Infection (pages 1277–1284)

      Hongshuai Li, Therwa Hamza, John E. Tidwell, Nina Clovis and Bingyun Li

      Article first published online: 27 FEB 2013 | DOI: 10.1002/adhm.201200465

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      Platelet-rich-plasma (PRP) shows unique antimicrobial properties both in vitro and in vivo. An implant-associated spinal infection rabbit model shows that PRP treatment leads to a significant reduction in bacterial burdens together with a significant improvement in wound healing. PRP could be an advanced healthcare material against postoperative implant-associated infections.

    8. 2D and 3D Nanopatterning of Titanium for Enhancing Osteoinduction of Stem Cells at Implant Surfaces (pages 1285–1293)

      Terje Sjöström, Laura E. McNamara, R. M. Dominic Meek, Matthew J. Dalby and Bo Su

      Article first published online: 12 MAR 2013 | DOI: 10.1002/adhm.201200353

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      A novel technique combining the precision of block copolymer templating with anodisation allows for highly defined nanopatterning of non-planar Ti surfaces. Highly ordered titania nanodots can be created, and the technique has the capability for fine tuning of topography dimensions. In vitro results show that these nanopatterns have the potential to improve osteoinduction at Ti implant surfaces.

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