Enhanced Tumor Accumulation of Sub-2 nm Gold Nanoclusters for Cancer Radiation Therapy (pages 133–141)
Xiao-Dong Zhang, Jie Chen, Zhentao Luo, Di Wu, Xiu Shen, Sha-Sha Song, Yuan-Ming Sun, Pei-Xun Liu, Jing Zhao, Shuaidong Huo, Saijun Fan, Feiyue Fan, Xing-Jie Liang and Jianping Xie
Article first published online: 22 JUL 2013 | DOI: 10.1002/adhm.201300189
A new type of radiosensitizers is developed by integrating an ultrasmall gold nanoclusters (NCs, <2 nm) with a biocompatible coating ligand (a naturally occurring biomolecule, e.g., glutathione, GSH) into a single entity. Both in vitro and in vivo data suggest that the GSH-protected gold NCs are a promising metabolizable and efficient radiosensitizer for cancer radiotherapy.