Reduction in Wound Bioburden using a Silver-Loaded Dissolvable Microfilm Construct (pages 916–928)
Maggie Herron, Ankit Agarwal, Patricia R. Kierski, Diego F. Calderon, Leandro B. C. Teixeira, Michael J. Schurr, Christopher J. Murphy, Charles J. Czuprynski, Jonathan F. McAnulty and Nicholas L. Abbott
Article first published online: 12 FEB 2014 | DOI: 10.1002/adhm.201300537
Silver is a well-known antimicrobial agent, yet, when used in wounds, it can lead to staining, tissue toxicity, and impairment of healing. Laminated constructs composed of silver-loaded polymeric nanofilms and micrometer-thick dissolvable casts provide a facile approach for delivery of silver to wounds. Therapeutic effects are measured at loadings and release rates of silver two orders of magnitude lower than conventional silver-loaded dressings.