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Covalent binding of glucose oxidase to functionalized polyazulenes. The first application of polyazulenes in amperometric biosensors

Authors

  • Dr. Wolfgang Schuhmann,

    Corresponding author
    1. Lehrstuhl für Allgemeine Chemie und Biochemie Technische Universität München Vöttingerstrasse 40, W-8050 Freising-Weihenstephan (FRG)
    • Institut für Organische Chemie, Universität Regensburg Universitätsstrasse 31, W-8400 Regensburg (FRG)
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  • Johanna Huber,

    1. Lehrstuhl für Allgemeine Chemie und Biochemie Technische Universität München Vöttingerstrasse 40, W-8050 Freising-Weihenstephan (FRG)
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  • Albert Mirlach,

    1. Institut für Organische Chemie, Universität Regensburg Universitätsstrasse 31, W-8400 Regensburg (FRG)
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  • Prof. Jörg Daub

    Corresponding author
    1. Institut für Organische Chemie, Universität Regensburg Universitätsstrasse 31, W-8400 Regensburg (FRG)
    • Lehrstuhl für Allgemeine Chemie und Biochemie Technische Universität München Vöttingerstrasse 40, W-8050 Freising-Weihenstephan (FRG)
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  • Polyazulenes, 5th communication, preceding ones, see ref. [5]. Contributing discussions and assistance in the use of the electrochemical equipment by Dr. J. Salbeck is gratefully acknowledged. Mrs. M. Feuerer contributed to the synthetic work.

Abstract

The covalent binding of enzymes to the surface of electrodes has been shown to lead to amperometric enzyme electrodes with fast response characteristics. New C-2 substituted azulenes offer a viable alternative to the use of pyrrole derivatives as electrode materials as they easily form thin films of conducting polymeric material on electrochemical doping (see Figure).

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