Get access
Advanced Materials

Engineering macromolecules self-assembly: Molecular tubes vs. protein sheets via single amino acid substitutions in E. coli glutamine synthetase

Authors

  • Dr. Michael J. Dabrowski,

    1. University of Washington Department of Medicinal Chemistry Box 357610, Seattle, WA 98195-7610 (USA) Foundation (#93-0272)
    Search for more papers by this author
  • Prof. William M. Atkins

    Corresponding author
    1. University of Washington Department of Medicinal Chemistry Box 357610, Seattle, WA 98195-7610 (USA) Foundation (#93-0272)
    • University of Washington Department of Medicinal Chemistry Box 357610, Seattle, WA 98195-7610 (USA) Foundation (#93-0272)
    Search for more papers by this author

  • This work was supported by NSF(#MCB-9305202) and by The Whitaker

Abstract

Protein engineering provides a rationale for obtaining self-assembling molecules which yield supramolecular arrays with varying quanternary architectures. An example is E. coli glutamine synthetase which can be manipulated to yield molecular tubes (see figure), cables, and hexagonally packed sheets

original image

.

Get access to the full text of this article

Ancillary