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Preserving a globular protein shape on glass slides: A self-assembled monolayer approach

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  • We gratefully acknowledge the antecedent of this report provided by Dr. Peter C. Ellingson in his Ph.D. dissertation from this laboratory. This work is supported in part by the Polymers Program of the National Science Foundation. USA (DMR-9203289). and by the Research Laboratories of Eastman Kodak Company.

Abstract

The manufacture of low-cost, protein-friendly, biocompatible materials is important for biomedical applications. A method is presented for making glass surfaces—on which the globular protein shape is often lost –benign to proteins by covalently grafting relatively short poly((ethylene glycol)) chains (functionalized with trimethylsilane, see Figure), which form a brush-like self-assembled monolayer.

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