A new biosensor design is demonstrated, in which a protein conformational change is used as a trigger mechanism for a low-cost, solid-state sensor (see also the cover). The figure illustrates the principle: an enzyme (hexokinase, large white shape) immobilized on a lipid polydiacetylene (PDA) layer undergoes a conformational change when glucose (dark shape) binds to it. The resulting stress in the PDA layer produces a color change.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.