Thermally responsive rigid polymer monoliths


  • Financial support of this research by the Office of Naval Research and the National Institutes of Health (GM-44885) is gratefully acknowledged. ECP thanks the Rohm and Haas company for its financial sponsorship.


A composite that changes its permeability with temperature–leading to the possibilites of a thermal gate, thermal valve, or thermal cotnrol of hydrophobicity/hydrophilicity–is reported. A method is described to modify the internal pore surface of rigid polymer moonoliths by grafting-on PNIPAAm, a temperature-responsive polymer. Isocratic hydrrophobic interaction chromatography of proteins is presented, which is a novel separation technique based on the changes in surface polarity (and thus adsorption) accompanying the temperature-induced phase transition of the grafted PNIPAAm.