Manfred T. Reetz was born in Hirschberg, Germany, but studied chemistry in the United States at Washington University, St. Louis, and the University of Michigan. He then returned to Germany, obtaining his doctorate in 1969 from the University of Göttingen and his habilitation in 1974 from the University of Marburg, in the field of dyotropic rearrangements. Between 1978 and 1980 he was a professor at Bonn University, after which he returned to the University of Marburg. Since 1993 he has been Director of the Max-Planck-Institut für Kohlenforschung in Mülheim an der Ruhr. His research interests lie in the development of new methods in synthetic organic chemistry, molecular recognition, and cluster chemistry.
Entrapment of biocatalysts in hydrophobic sol-gel materials for use in organic chemistry†
Article first published online: 29 OCT 2004
Copyright © 1997 Verlag GmbH & Co. KGaA, Weinheim
Volume 9, Issue 12, pages 943–954, 1997
How to Cite
Reetz, M. T. (1997), Entrapment of biocatalysts in hydrophobic sol-gel materials for use in organic chemistry. Adv. Mater., 9: 943–954. doi: 10.1002/adma.19970091203
I thank my co-workers A. Zonta, J. Simpelkamp, K. Schimossek, W. Konen, and R. Wenkel for their enthusiastic and creative participation in this project; A. Rufinska and B. Tesche for help in the characterization of the gels; and K. E. Jaeger and his students at the Lehrstuhl Biologie der Mikroorganismen (Universität Bochum) for a very fruitful on-going collaboration.
- Issue published online: 29 OCT 2004
- Article first published online: 29 OCT 2004
- Manuscript Revised: 21 MAY 1997
- Manuscript Received: 27 MAR 1997
Lipases trapped in hydrophobic organic/inorganic materials result in chemically and thermally stable heterogeneous catalysts that display unusually high catalytic activities. The entrapment of lipases and other biocatalysts by sol-gel encapsulation is an interesting approach to enzyme immobilization, which has the aim of increasing enzyme activity in organic solvents. Investigations that have been carried out to optimize encapsulation and to characterize the lipase-containing gels are reviewed. Possible applications in organic synthesis are indicated.