Review

Peptide and Protein Presenting Materials for Tissue Engineering†

  1. Y. Hirano3,
  2. D. J. Mooney2

Article first published online: 16 JAN 2004

DOI: 10.1002/adma.200300383

Issue

Advanced Materials

Advanced Materials

Volume 16, Issue 1, pages 17–25, January, 2004

Additional Information

How to Cite

Hirano, Y. and Mooney, D. J. (2004), Peptide and Protein Presenting Materials for Tissue Engineering. Adv. Mater., 16: 17–25. doi: 10.1002/adma.200300383

Author Information

  1. 2

    Dental School, University of Michigan, 1011 N. University Ave., Ann Arbor, MI 48109-1078, USA

  2. 3

    Department of Applied Chemistry, Osaka Institute of Technology, 5-16-1 Ohmiya, Asahi-ku, Osaka 535-8585, Japan

  1. †

    The authors gratefully acknowledge funding for their research in this area from the National Institute of Dental and Craniofacial Research (NIH).

Publication History

  1. Issue published online: 16 JAN 2004
  2. Article first published online: 16 JAN 2004
  3. Manuscript Accepted: 8 AUG 2003
  4. Manuscript Received: 12 MAR 2003

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Keywords:

  • Biomaterials;
  • Peptides;
  • Proteins;
  • Tissue Engineering

Abstract

Tissue engineering aims to create new tissues and organs to replace those lost to disease, trauma, or congenital defects. However, considerable instruction must be given to the cells forming these new tissues if one is to create a tissue structurally and functionally similar to the native tissue. Materials are ideal for the local presentation of various peptides and proteins that can bind to cell surface receptors and regulate cell function. An overview of techniques to present peptides and proteins from materials, and the utility of these systems in engineering tissues in vitro and in vivo is presented.

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