Does a signal protein imbedded in a polyelectrolyte layer keep its activity? The study reported here demonstrates that cells can indeed interact with proteins incorporated in poly(L-lysine/glutamic acid) multilayer films. In contrast, poly(D-lysine) acts as a barrier to cell communication. For the case of monocytic cells the mechanism of contact with the active protein is elucidated. It is believed that such functionalized coatings could be useful tools for the modification of biomaterial surfaces with applications in, e.g., implants or tissue engineering.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.