A Miniaturized Enzyme Reactor Based on Hierarchically Shaped Porous Ceramic Microstruts


  • The authors thank Prof. J. Dual and S. Blunier at the Institute of Mechanical Systems IMES at ETHZ for generously providing access to all clean room equipment. Dr. R. Schoenmakers and Prof. J. Hubbell are gratefully acknowledged for inviting us to perform the fluorescence experiments at their institute. We also thank Hans Wyss for acquiring the Hg porosimetry data.


A microfluidic continuous flow enzyme reactor consisting of porous ceramic microstruts mounted inside polydimethylsiloxane (PDMS) channels has been built (see Figure). This is a novel multifunctional approach combining the biocompatibility of ceramics, enzyme immobilization, and high specific surface area of the ceramic microstructures, Also it tackles the mixing problems due to laminar flow often encountered in microfluidic systems.