Hydrophilic Interface-Directed Self-Assembly of Bola-Form Amide into Hollow Spheres



Stable submicrometer-sized hollow spheres of bola-form amide (see Figure) are formed in aqueous solution via non-covalent interactions induced by the presence of a hydrophilic substrate. Rod-like micelles self-assemble to form spherical vesicles, which, in the presence of the substrate, gather to form spherical hollow particles. In contrast, when no substrate is present, the spherical vesicles to self-assemble into fibers.