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Advanced Materials

Hydrogel Formation via Cell Crosslinking


  • The authors acknowledge the NIH (R01 DE13033) and the University of Michigan Cardiovascular Center (McKay grant) for their financial support.


It is demonstrated that cells can be utilized as a crosslinker to form network structures from polymers. The properties of these systems can be interpreted with classical network theory. This approach can be useful to determine various parameters related to cell receptor–ligand binding (see Figure), such as the number of bonds, as well as to suggest a unique means to the delivery of cells for therapeutic purposes.

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