Surface-Initiated, Enzymatic Polymerization of Biodegradable Polyesters


  • This work was supported by the Korea Research Foundation Grant (KRF-2002–015-CP0177). We thank Dr. Young-Hye La and Prof. Joon Won Park of the Department of Chemistry at Pohang University of Science and Technology for help with IR and ellipsometry experiments, and Dr. Won in the Korea Basic Science Institute (KBSI) for obtaining XPS data.


Enzyme-catalyzed, ring-opening polymerization of biodegradable aliphatic polyesters has successfully been applied to surface-initiated polymerization (see Figure). Using lipase B as a catalyst, a thin film of poly(ϵ-caprolactone) (PCL) and poly(p-dioxanone) (PPDX) on a gold substrate (after a formation of self-assembled monolayers terminating in hydroxyl groups) is formed.