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Advanced Materials

Development of Organic-Dye-Doped Silica Nanoparticles in a Reverse Microemulsion


  • This work is partially supported by NIH NCI CA92581 and R01 GM66137–01, and by the Packard Foundation Science and Technology Award.


A new synthesis method to produce various organic-dye-doped silica nanoparticles using a reverse microemulsion has been developed. These nanoparticles show extremely high fluorescent signals (see Figure), excellent photostability, and size uniformity and tenability. These dye-doped silica nanoparticles can be used for various applications, especially in ultra-sensitive bioanalysis and in biomedical monitoring.

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