“Non-Fouling” Oligo(ethylene glycol)- Functionalized Polymer Brushes Synthesized by Surface-Initiated Atom Transfer Radical Polymerization


  • The authors thank Leslie Eibest for help with the SEM (SEM acquired through NSF award DBI-0098534). This work was partially supported by the Center for Biologically Inspired Materials and Materials System (CBIMMS) at Duke University and by the NSF through grant EEC-0210590).


The in-situ synthesis of oligo(ethylene glycol)-functionalized polymer brushes from a self-assembled monolayer of an alkanethiol on gold that presents a tethered initiator by surface-initiated atom transfer radical polymerization is reported. These polymer brushes exhibit no detectable adsorption of proteins, and are cell-resistant for up to a month under typical cell culture conditions. The synthesis method is compatible with a range of patterning techniques from the nano- to the microscale, and enables the patterning of cells in a biologically relevant milieu over extended periods of time. Images of the brushes are shown on the inside front cover.