Highly Efficient Biocatalysts via Covalent Immobilization of Candida rugosa Lipase on Ethylene Glycol-Modified Gold–Silica Nanocomposites


  • This research was supported by the NIH (GM62998) and the NSF (DMR-0213695, MRSEC).


The polymer-mediated self-assembly of silica and gold nanoparticles (see inset in Figure and cover) leads to extended aggregates. After calcination and subsequent surface modification, these aggregates serve as supports for the covalent immobilization of lipase (see Scheme). The obtained biocatalysts exhibit high efficiencies and long-term stability.