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Highly Efficient Biocatalysts via Covalent Immobilization of Candida rugosa Lipase on Ethylene Glycol-Modified Gold–Silica Nanocomposites†

  1. U. Drechsler,
  2. N. O. Fischer,
  3. B. L. Frankamp,
  4. V. M. Rotello

Article first published online: 11 FEB 2004

DOI: 10.1002/adma.200306022

Issue

Advanced Materials

Advanced Materials

Volume 16, Issue 3, pages 271–274, February, 2004

Additional Information

How to Cite

Drechsler, U., Fischer, N., Frankamp, B. and Rotello, V. (2004), Highly Efficient Biocatalysts via Covalent Immobilization of Candida rugosa Lipase on Ethylene Glycol-Modified Gold–Silica Nanocomposites. Advanced Materials, 16: 271–274. doi: 10.1002/adma.200306022

Author Information

  1. Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA

  1. †

    This research was supported by the NIH (GM62998) and the NSF (DMR-0213695, MRSEC).

Publication History

  1. Issue published online: 11 FEB 2004
  2. Article first published online: 11 FEB 2004
  3. Manuscript Accepted: 23 OCT 2003
  4. Manuscript Received: 18 AUG 2003

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Keywords:

  • Biocatalysts;
  • Gold;
  • Nanocomposites;
  • Silica

The polymer-mediated self-assembly of silica and gold nanoparticles (see inset in Figure and cover) leads to extended aggregates. After calcination and subsequent surface modification, these aggregates serve as supports for the covalent immobilization of lipase (see Scheme). The obtained biocatalysts exhibit high efficiencies and long-term stability.

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