Chemically Modified Calcium Phosphates as Novel Materials for Bisphosphonate Delivery


  • This work was partially supported by the French Ministry of Research (ACI “Technologies pour la Santé”), the C.N.R.S. (Programme “Matériaux Nouveaux–Fonctionnalités Nouvelles”) and the “Fondation de l'avenir pour la recherche médicale appliquée”. Partial support from the Région Pays de la Loire (CPER “Biomatériaux–S3”) is also acknowledged. We thank Novartis Pharma Research (Basel) for a generous gift of zoledronate and J. R. Green (Novartis Pharma Research) for fruitful discussion. We thank Paul Pilet for technical assistance. Supporting Information is available online from Wiley Interscience or from the author.


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A potent inhibitor for bone resorption, the gem-bisphosphonate zoledronate, has been chemically associated with calcium-deficient apatites. The ability of such materials to release the zoledronate, resulting in the inhibition of osteoclastic resorption, is demonstrated using a specific in-vitro bone resorption model. The resorption activity is typically characterized by the formation of lacunae on the surface of dentin slices (see Figure).