We thank Annelise Barron for use of the peptide synthesizer, Mark Johnson, Bert Menco and Jiahn-Dar Huang for assistance with QFDE, and Arthur Veis for use of the TEM. This research was supported by NIH grant DE 13030.
Self-Assembling Polymer–Peptide Conjugates: Nanostructural Tailoring†
Article first published online: 17 JUN 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 16, Issue 11, pages 907–910, June, 2004
How to Cite
Collier, J. H. and Messersmith, P. B. (2004), Self-Assembling Polymer–Peptide Conjugates: Nanostructural Tailoring. Adv. Mater., 16: 907–910. doi: 10.1002/adma.200306379
- Issue published online: 17 JUN 2004
- Article first published online: 17 JUN 2004
- Manuscript Accepted: 10 MAR 2004
- Manuscript Received: 29 OCT 2003
- Peptides, poly-;
- Polmer conjugates;
The synthesis and solution behavior of a series of β-sheet fibril-forming peptide–polymers is described. Several block copolymer architectures are explored, with various lengths and arrangements of the peptide and polymer blocks. One peptide–polymer, an 11-amino acid peptide conjugated to a polydisperse poly(ethylene glycol) chain, has the ability to form uncommonly regular, aligned, and minimally aggregated β-sheet fibrils (see Figure).