Communication

Self-Assembling Polymer–Peptide Conjugates: Nanostructural Tailoring†

  1. J. H. Collier,
  2. P. B. Messersmith

Article first published online: 17 JUN 2004

DOI: 10.1002/adma.200306379

Issue

Advanced Materials

Advanced Materials

Volume 16, Issue 11, pages 907–910, June, 2004

Additional Information

How to Cite

Collier, J. H. and Messersmith, P. B. (2004), Self-Assembling Polymer–Peptide Conjugates: Nanostructural Tailoring. Adv. Mater., 16: 907–910. doi: 10.1002/adma.200306379

Author Information

  1. Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Room E310, Evanston, IL 60208, 847-467-5273, USA

  1. †

    We thank Annelise Barron for use of the peptide synthesizer, Mark Johnson, Bert Menco and Jiahn-Dar Huang for assistance with QFDE, and Arthur Veis for use of the TEM. This research was supported by NIH grant DE 13030.

Publication History

  1. Issue published online: 17 JUN 2004
  2. Article first published online: 17 JUN 2004
  3. Manuscript Accepted: 10 MAR 2004
  4. Manuscript Received: 29 OCT 2003

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Keywords:

  • Nanostructuring;
  • Patterning;
  • Peptides, poly-;
  • Polmer conjugates;
  • Self-assembly

The synthesis and solution behavior of a series of β-sheet fibril-forming peptide–polymers is described. Several block copolymer architectures are explored, with various lengths and arrangements of the peptide and polymer blocks. One peptide–polymer, an 11-amino acid peptide conjugated to a polydisperse poly(ethylene glycol) chain, has the ability to form uncommonly regular, aligned, and minimally aggregated β-sheet fibrils (see Figure).

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