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Keywords:

  • Nanostructuring;
  • Patterning;
  • Peptides, poly-;
  • Polmer conjugates;
  • Self-assembly

The synthesis and solution behavior of a series of β-sheet fibril-forming peptide–polymers is described. Several block copolymer architectures are explored, with various lengths and arrangements of the peptide and polymer blocks. One peptide–polymer, an 11-amino acid peptide conjugated to a polydisperse poly(ethylene glycol) chain, has the ability to form uncommonly regular, aligned, and minimally aggregated β-sheet fibrils (see Figure).