Communication

Coiled-Coil Peptide-Based Assembly of Gold Nanoparticles†

  1. M. M. Stevens1,2,
  2. N. T. Flynn1,
  3. C. Wang1,
  4. D. A. Tirrell3,
  5. R. Langer

Article first published online: 20 APR 2004

DOI: 10.1002/adma.200306430

Issue

Advanced Materials

Advanced Materials

Volume 16, Issue 11, pages 915–918, June, 2004

Additional Information

How to Cite

Stevens, M. M., Flynn, N. T., Wang, C., Tirrell, D. A. and Langer, R. (2004), Coiled-Coil Peptide-Based Assembly of Gold Nanoparticles. Adv. Mater., 16: 915–918. doi: 10.1002/adma.200306430

Author Information

  1. 1

    Department of Chemical Engineering, Massachusetts Institute of Technology, 45 Carleton Street, Cambridge, MA 02139, USA

  2. 2

    Department of Materials, Imperial College, Exhibition Road, London, SW7 2AZ, UK

  3. 3

    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA

  1. †

    We thank Professor Robert Sauer for the use of the Aviv spectropolarimeter and Jill Sakata for help with the bacterial expression of the peptides. We acknowledge the support of the National Institutes of Health (Grant #DE-13023).

Publication History

  1. Issue published online: 17 JUN 2004
  2. Article first published online: 20 APR 2004
  3. Manuscript Accepted: 23 JAN 2004
  4. Manuscript Received: 6 NOV 2003

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Keywords:

  • Nanoparticles;
  • Peptides;
  • Self-assembly

The coiled-coil-based assembly of gold nanoparticles (see Figure and cover) is demonstrated. Control over the assembly and disassembly of nanostructures is achieved under mild conditions (near-neutral pH and ambient temperature). The flexibility in design afforded by varying the peptide sequence to produce coiled coils with different stabilities is also highlighted by the generation of more stable binary nanoparticle systems with controlled spacing and architecture.

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