Coiled-Coil Peptide-Based Assembly of Gold Nanoparticles


  • We thank Professor Robert Sauer for the use of the Aviv spectropolarimeter and Jill Sakata for help with the bacterial expression of the peptides. We acknowledge the support of the National Institutes of Health (Grant #DE-13023).


The coiled-coil-based assembly of gold nanoparticles (see Figure and cover) is demonstrated. Control over the assembly and disassembly of nanostructures is achieved under mild conditions (near-neutral pH and ambient temperature). The flexibility in design afforded by varying the peptide sequence to produce coiled coils with different stabilities is also highlighted by the generation of more stable binary nanoparticle systems with controlled spacing and architecture.