Biodegradable Microfluidics


  • This project was sponsored by the Department of the Army, Cooperative Agreement DAMD-99-2-9001. The content of this paper does not necessarily reflect the position or the policy of the government, and no official endorsement should be inferred.


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A biodegradable microfabrication platform for constructing 3D high- resolution devices for tissue engineering and drug delivery is presented. Biodegradable polymer films with built-in micrometer-scale features are stacked and fusion bonded to construct fully biodegradable, poly(DL-lactic-co-glycolide) (PLGA)-based, monolithic, multilayer, microfluidic networks. Integration with cells or drug compounds will enable use of these devices in therapeutic applications (scale bar: ∼ 300 μm).